Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses

L. Okolicsanyi, M. Venuti, M. Strazzabosco, A. Biral, R. Orlando, R. M. Iemmolo, G. Nassuato, M. Muraca, G. Padrini, P. A. Miglioli

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The pharmacokinetics of Josamycin was studied in 31 subjects (10 normals, 9 Gilbert's syndrome and 12 compensated liver cirrhosis) after the administration of Josamycin (1 g orally) and in 13 subjects (4 normals, 4 Gilbert's syndrome and 5 compensated liver cirrhosis) after 3-day Josamycin treatment (1 g orally every 12 hours). Josamycin pharmacokinetics was impaired in liver cirrhosis and, to a lesser extent, in Gilbert's syndrome. Moreover, in the three groups of individuals studied the drug accumulated after multiple dosing. These results suggest that a dosage adjustment of Josamycin is recommended when dealing with these patients.

Original languageEnglish
Pages (from-to)434-438
Number of pages5
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Volume23
Issue number8
Publication statusPublished - 1985

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Josamycin
Gilbert Disease
Pharmacokinetics
Liver Cirrhosis
Liver
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Cite this

Okolicsanyi, L., Venuti, M., Strazzabosco, M., Biral, A., Orlando, R., Iemmolo, R. M., ... Miglioli, P. A. (1985). Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses. International Journal of Clinical Pharmacology Therapy and Toxicology, 23(8), 434-438.

Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses. / Okolicsanyi, L.; Venuti, M.; Strazzabosco, M.; Biral, A.; Orlando, R.; Iemmolo, R. M.; Nassuato, G.; Muraca, M.; Padrini, G.; Miglioli, P. A.

In: International Journal of Clinical Pharmacology Therapy and Toxicology, Vol. 23, No. 8, 1985, p. 434-438.

Research output: Contribution to journalArticle

Okolicsanyi, L, Venuti, M, Strazzabosco, M, Biral, A, Orlando, R, Iemmolo, RM, Nassuato, G, Muraca, M, Padrini, G & Miglioli, PA 1985, 'Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses', International Journal of Clinical Pharmacology Therapy and Toxicology, vol. 23, no. 8, pp. 434-438.
Okolicsanyi, L. ; Venuti, M. ; Strazzabosco, M. ; Biral, A. ; Orlando, R. ; Iemmolo, R. M. ; Nassuato, G. ; Muraca, M. ; Padrini, G. ; Miglioli, P. A. / Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses. In: International Journal of Clinical Pharmacology Therapy and Toxicology. 1985 ; Vol. 23, No. 8. pp. 434-438.
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