Abstract
The pharmacokinetics of Josamycin was studied in 31 subjects (10 normals, 9 Gilbert's syndrome and 12 compensated liver cirrhosis) after the administration of Josamycin (1 g orally) and in 13 subjects (4 normals, 4 Gilbert's syndrome and 5 compensated liver cirrhosis) after 3-day Josamycin treatment (1 g orally every 12 hours). Josamycin pharmacokinetics was impaired in liver cirrhosis and, to a lesser extent, in Gilbert's syndrome. Moreover, in the three groups of individuals studied the drug accumulated after multiple dosing. These results suggest that a dosage adjustment of Josamycin is recommended when dealing with these patients.
Original language | English |
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Pages (from-to) | 434-438 |
Number of pages | 5 |
Journal | International Journal of Clinical Pharmacology Therapy and Toxicology |
Volume | 23 |
Issue number | 8 |
Publication status | Published - 1985 |
ASJC Scopus subject areas
- Toxicology
- Pharmacology (medical)