Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses

L. Okolicsanyi; M. Venuti; M. Strazzabosco; A. Biral; R. Orlando; R. M. Iemmolo; G. Nassuato; M. Muraca; G. Padrini; P. A. Miglioli

Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses

L. Okolicsanyi, M. Venuti, M. Strazzabosco, A. Biral, R. Orlando, R. M. Iemmolo, G. Nassuato, M. Muraca, G. Padrini, P. A. Miglioli

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

The pharmacokinetics of Josamycin was studied in 31 subjects (10 normals, 9 Gilbert's syndrome and 12 compensated liver cirrhosis) after the administration of Josamycin (1 g orally) and in 13 subjects (4 normals, 4 Gilbert's syndrome and 5 compensated liver cirrhosis) after 3-day Josamycin treatment (1 g orally every 12 hours). Josamycin pharmacokinetics was impaired in liver cirrhosis and, to a lesser extent, in Gilbert's syndrome. Moreover, in the three groups of individuals studied the drug accumulated after multiple dosing. These results suggest that a dosage adjustment of Josamycin is recommended when dealing with these patients.

Original language	English
Pages (from-to)	434-438
Number of pages	5
Journal	International Journal of Clinical Pharmacology Therapy and Toxicology
Volume	23
Issue number	8
Publication status	Published - 1985

ASJC Scopus subject areas

Toxicology
Pharmacology (medical)

Fingerprint Dive into the research topics of 'Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses'. Together they form a unique fingerprint.

Cite this

Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses. / Okolicsanyi, L.; Venuti, M.; Strazzabosco, M.; Biral, A.; Orlando, R.; Iemmolo, R. M.; Nassuato, G.; Muraca, M.; Padrini, G.; Miglioli, P. A.

In: International Journal of Clinical Pharmacology Therapy and Toxicology, Vol. 23, No. 8, 1985, p. 434-438.

Research output: Contribution to journal › Article › peer-review

Okolicsanyi, L. ; Venuti, M. ; Strazzabosco, M. ; Biral, A. ; Orlando, R. ; Iemmolo, R. M. ; Nassuato, G. ; Muraca, M. ; Padrini, G. ; Miglioli, P. A. / Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses. In: International Journal of Clinical Pharmacology Therapy and Toxicology. 1985 ; Vol. 23, No. 8. pp. 434-438.

@article{2802b302eec847d7ba7d5ca2c92156b2,

title = "Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses",

abstract = "The pharmacokinetics of Josamycin was studied in 31 subjects (10 normals, 9 Gilbert's syndrome and 12 compensated liver cirrhosis) after the administration of Josamycin (1 g orally) and in 13 subjects (4 normals, 4 Gilbert's syndrome and 5 compensated liver cirrhosis) after 3-day Josamycin treatment (1 g orally every 12 hours). Josamycin pharmacokinetics was impaired in liver cirrhosis and, to a lesser extent, in Gilbert's syndrome. Moreover, in the three groups of individuals studied the drug accumulated after multiple dosing. These results suggest that a dosage adjustment of Josamycin is recommended when dealing with these patients.",

author = "L. Okolicsanyi and M. Venuti and M. Strazzabosco and A. Biral and R. Orlando and Iemmolo, {R. M.} and G. Nassuato and M. Muraca and G. Padrini and Miglioli, {P. A.}",

year = "1985",

language = "English",

volume = "23",

pages = "434--438",

journal = "International Journal of Clinical Pharmacology and Therapeutics",

issn = "0174-4879",

publisher = "Dustri-Verlag Dr. Karl Feistle",

number = "8",

}

TY - JOUR

T1 - Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses

AU - Okolicsanyi, L.

AU - Venuti, M.

AU - Strazzabosco, M.

AU - Biral, A.

AU - Orlando, R.

AU - Iemmolo, R. M.

AU - Nassuato, G.

AU - Muraca, M.

AU - Padrini, G.

AU - Miglioli, P. A.

PY - 1985

Y1 - 1985

N2 - The pharmacokinetics of Josamycin was studied in 31 subjects (10 normals, 9 Gilbert's syndrome and 12 compensated liver cirrhosis) after the administration of Josamycin (1 g orally) and in 13 subjects (4 normals, 4 Gilbert's syndrome and 5 compensated liver cirrhosis) after 3-day Josamycin treatment (1 g orally every 12 hours). Josamycin pharmacokinetics was impaired in liver cirrhosis and, to a lesser extent, in Gilbert's syndrome. Moreover, in the three groups of individuals studied the drug accumulated after multiple dosing. These results suggest that a dosage adjustment of Josamycin is recommended when dealing with these patients.

AB - The pharmacokinetics of Josamycin was studied in 31 subjects (10 normals, 9 Gilbert's syndrome and 12 compensated liver cirrhosis) after the administration of Josamycin (1 g orally) and in 13 subjects (4 normals, 4 Gilbert's syndrome and 5 compensated liver cirrhosis) after 3-day Josamycin treatment (1 g orally every 12 hours). Josamycin pharmacokinetics was impaired in liver cirrhosis and, to a lesser extent, in Gilbert's syndrome. Moreover, in the three groups of individuals studied the drug accumulated after multiple dosing. These results suggest that a dosage adjustment of Josamycin is recommended when dealing with these patients.

UR - http://www.scopus.com/inward/record.url?scp=0021807757&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021807757&partnerID=8YFLogxK

M3 - Article

C2 - 4044077

AN - SCOPUS:0021807757

VL - 23

SP - 434

EP - 438

JO - International Journal of Clinical Pharmacology and Therapeutics

JF - International Journal of Clinical Pharmacology and Therapeutics

SN - 0174-4879

IS - 8

ER -