Abstract
The pharmacokinetics of Josamycin was studied in 31 subjects (10 normals, 9 Gilbert's syndrome and 12 compensated liver cirrhosis) after the administration of Josamycin (1 g orally) and in 13 subjects (4 normals, 4 Gilbert's syndrome and 5 compensated liver cirrhosis) after 3-day Josamycin treatment (1 g orally every 12 hours). Josamycin pharmacokinetics was impaired in liver cirrhosis and, to a lesser extent, in Gilbert's syndrome. Moreover, in the three groups of individuals studied the drug accumulated after multiple dosing. These results suggest that a dosage adjustment of Josamycin is recommended when dealing with these patients.
| Original language | English |
|---|---|
| Pages (from-to) | 434-438 |
| Number of pages | 5 |
| Journal | International Journal of Clinical Pharmacology Therapy and Toxicology |
| Volume | 23 |
| Issue number | 8 |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Toxicology
- Pharmacology (medical)
Cite this
Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses. / Okolicsanyi, L.; Venuti, M.; Strazzabosco, M.; Biral, A.; Orlando, R.; Iemmolo, R. M.; Nassuato, G.; Muraca, M.; Padrini, G.; Miglioli, P. A.
In: International Journal of Clinical Pharmacology Therapy and Toxicology, Vol. 23, No. 8, 1985, p. 434-438.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses
AU - Okolicsanyi, L.
AU - Venuti, M.
AU - Strazzabosco, M.
AU - Biral, A.
AU - Orlando, R.
AU - Iemmolo, R. M.
AU - Nassuato, G.
AU - Muraca, M.
AU - Padrini, G.
AU - Miglioli, P. A.
PY - 1985
Y1 - 1985
N2 - The pharmacokinetics of Josamycin was studied in 31 subjects (10 normals, 9 Gilbert's syndrome and 12 compensated liver cirrhosis) after the administration of Josamycin (1 g orally) and in 13 subjects (4 normals, 4 Gilbert's syndrome and 5 compensated liver cirrhosis) after 3-day Josamycin treatment (1 g orally every 12 hours). Josamycin pharmacokinetics was impaired in liver cirrhosis and, to a lesser extent, in Gilbert's syndrome. Moreover, in the three groups of individuals studied the drug accumulated after multiple dosing. These results suggest that a dosage adjustment of Josamycin is recommended when dealing with these patients.
AB - The pharmacokinetics of Josamycin was studied in 31 subjects (10 normals, 9 Gilbert's syndrome and 12 compensated liver cirrhosis) after the administration of Josamycin (1 g orally) and in 13 subjects (4 normals, 4 Gilbert's syndrome and 5 compensated liver cirrhosis) after 3-day Josamycin treatment (1 g orally every 12 hours). Josamycin pharmacokinetics was impaired in liver cirrhosis and, to a lesser extent, in Gilbert's syndrome. Moreover, in the three groups of individuals studied the drug accumulated after multiple dosing. These results suggest that a dosage adjustment of Josamycin is recommended when dealing with these patients.
UR - http://www.scopus.com/inward/record.url?scp=0021807757&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021807757&partnerID=8YFLogxK
M3 - Article
C2 - 4044077
AN - SCOPUS:0021807757
VL - 23
SP - 434
EP - 438
JO - International Journal of Clinical Pharmacology and Therapeutics
JF - International Journal of Clinical Pharmacology and Therapeutics
SN - 0174-4879
IS - 8
ER -