Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses

L. Okolicsanyi, M. Venuti, M. Strazzabosco, A. Biral, R. Orlando, R. M. Iemmolo, G. Nassuato, M. Muraca, G. Padrini, P. A. Miglioli

Research output: Contribution to journalArticlepeer-review

Abstract

The pharmacokinetics of Josamycin was studied in 31 subjects (10 normals, 9 Gilbert's syndrome and 12 compensated liver cirrhosis) after the administration of Josamycin (1 g orally) and in 13 subjects (4 normals, 4 Gilbert's syndrome and 5 compensated liver cirrhosis) after 3-day Josamycin treatment (1 g orally every 12 hours). Josamycin pharmacokinetics was impaired in liver cirrhosis and, to a lesser extent, in Gilbert's syndrome. Moreover, in the three groups of individuals studied the drug accumulated after multiple dosing. These results suggest that a dosage adjustment of Josamycin is recommended when dealing with these patients.

Original languageEnglish
Pages (from-to)434-438
Number of pages5
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Volume23
Issue number8
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses'. Together they form a unique fingerprint.

Cite this