Pharmacokinetics of lisuride after subcutaneous infusion.

W. Krause, B. Nieuweboer, S. Ruggieri, F. Stocchi, I. Suchy

Research output: Contribution to journalArticle

Abstract

Six parkinsonian patients received a constant subcutaneous infusion of 60 micrograms lisuride per hour in the abdominal region for 2 hours. Plasma levels of the unchanged drug were measured by radio-immunoassay. During infusion, a steady state plasma level of 0.78 +/- 0.19 ng/ml was achieved. After discontinuation of the infusion, concentrations declined with a half-life of 1.4 +/- 0.4 hour. The total clearance of lisuride was 20 +/- 6 ml/min/kg. Due to the low interpatient variability of plasma levels, a good control of clinical effects is to be expected.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalJournal of Neural Transmission, Supplement
Volume27
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Neuroscience(all)

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    Krause, W., Nieuweboer, B., Ruggieri, S., Stocchi, F., & Suchy, I. (1988). Pharmacokinetics of lisuride after subcutaneous infusion. Journal of Neural Transmission, Supplement, 27, 71-74.