Pharmacokinetics of nomifensine in man

L. Vereczkey, G. Bianchetti, S. Garattini, P. L. Morselli

Research output: Contribution to journalArticle

Abstract

Nomifensine pharmacokinetics were determined in healthy volunteers after the oral administration of 50 mg of the drug. Peak plasma levels of 95-177 ng/ml were attained within 1 to 4 hrs, and the apparent plasma half-lives ranged from 3.3 to 4.9 hrs. Assuming 100% bioavailability the drug has a relatively large apparent volume of distribution. From these findings it appears that the pharmacokinetics profile of nomifensine is considerably different from those of other known antidepressants. Implications for dosages schedules are discussed.

Original languageEnglish
Pages (from-to)225-227
Number of pages3
JournalPsychopharmacology
Volume45
Issue number2
DOIs
Publication statusPublished - Jan 1975

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Keywords

  • Kinetics
  • Nomifensine
  • Plasma levels
  • Volunteers

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

Vereczkey, L., Bianchetti, G., Garattini, S., & Morselli, P. L. (1975). Pharmacokinetics of nomifensine in man. Psychopharmacology, 45(2), 225-227. https://doi.org/10.1007/BF00429065