Pharmacokinetics of oxiracetam following intravenous and oral administration in healthy volunteers

E. Perucca, A. Albrici, G. Gatti, R. Spalluto, M. Visconti, A. Crema

Research output: Contribution to journalArticlepeer-review

Abstract

The kinetics of oxiracetam after single intravenous and oral doses (2000 mg) were investigated in four healthy volunteers. Following intravenous administration, the decline in serum levels showed a prolonged, rapid phase followed by a delayed terminal phase. Mean residence times ranged from 3.9 to 6.5 h. Volumes of distribution ranged from 0.9 to 1.81 · kg-1, whereas clearance values ranged from 100 to 119 ml·.h-1· kg -1 More than 90% of the intravenous dose was recovered unchanged in the urine within 48 h. Oral administration resulted in peak levels within 1-2 h; thereafter, the decline in serum levels showed a pattern similar to that observed after the intravenous dose - almost 50% of the oral dose was excreted in the urine within 6 h. The absolute availability of oral oxiracetam was 75 ± 7%.

Original languageEnglish
Pages (from-to)267-274
Number of pages8
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume9
Issue number3
DOIs
Publication statusPublished - Jul 1984

Keywords

  • bioavailability
  • oxiracetam
  • Pharmacokinetics

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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