The pharmacokinetics of phenylethylmalonamide (PEMA), a major metabolite of primidone, were investigated following administration of single oral doses (400 mg) to 6 normal subjects and 6 patients receiving chronic treatment with antiepileptic drugs. Peak serum PEMA levels were usually attained within 2-4 h after intake. The oral bioavailability estimated on the basis of the recovery of unchanged drug in the urine of normal subjects was at least 80%. Half-life values ranged from 17 to 25 h in normal subjects and from 10 to 23 h in the patients. No statistically significant difference in any of the calculated kinetic parameters could be found between the 2 groups. The data indicate that PEMA is readily absorbed from the gastrointestinal tract and that it is eliminated predominantly unchanged in the urine of man.
|Number of pages||7|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Clinical Neurology