Pharmacokinetics of phenytoin following intravenous administration in epileptic patients

G. Gatti, E. Perucca, M. Caravaggi, M. Poloni, G. M. Frigo, A. Crema

Research output: Chapter in Book/Report/Conference proceedingChapter


The pharmacokinetics of phenytoin has been studied in 5 epileptic patients after administration of single intravenous doses (250 mg). Plasma levels at all sampling times showed high variability among individuals. Phenytoin concentrations declined over the first 1-2 hr following the injection, then rose again producing a delayed peak after about 4 hr. The decline of the log-plasma concentration with time appeared to be linear after the 6th hr. Half lives ranged from 10 to 14 hr. Apparent volumes of distribution ranged between 0.27 and 1.09 l/kg. The kinetic factors responsible for the observed large differences in plasma levels and the therapeutic implications are discussed.

Original languageEnglish
Title of host publicationFarmaco, Edizione Pratica
Number of pages5
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Molecular Medicine


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