Pharmacokinetics of phenytoin following intravenous administration in epileptic patients

G. Gatti, E. Perucca, M. Caravaggi, M. Poloni, G. M. Frigo, A. Crema

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The pharmacokinetics of phenytoin has been studied in 5 epileptic patients after administration of single intravenous doses (250 mg). Plasma levels at all sampling times showed high variability among individuals. Phenytoin concentrations declined over the first 1-2 hr following the injection, then rose again producing a delayed peak after about 4 hr. The decline of the log-plasma concentration with time appeared to be linear after the 6th hr. Half lives ranged from 10 to 14 hr. Apparent volumes of distribution ranged between 0.27 and 1.09 l/kg. The kinetic factors responsible for the observed large differences in plasma levels and the therapeutic implications are discussed.

Original languageEnglish
Title of host publicationFarmaco, Edizione Pratica
Pages470-474
Number of pages5
Volume32
Edition9
Publication statusPublished - 1977

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ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Gatti, G., Perucca, E., Caravaggi, M., Poloni, M., Frigo, G. M., & Crema, A. (1977). Pharmacokinetics of phenytoin following intravenous administration in epileptic patients. In Farmaco, Edizione Pratica (9 ed., Vol. 32, pp. 470-474)