Pharmacokinetics of prednisone and its metabolite prednisolone in children with nephrotic syndrome during the active phase and in remission.

G. Gatti, E. Perucca, GM Frigo, LD Notarangelo, L. Barberis, A. Martini

Research output: Contribution to journalArticle

Abstract

The kinetics at steady state of prednisone and its metabolite prednisolone were determined in nine nephrotic children during the active phase of the disease and in remission. There were no differences in serum prednisone levels between the two occasions. Prednisone levels were lower than prednisolone levels. Total serum prednisolone levels were significantly lower during the active phase than in remission (AUC: 2452 +/‐ 207 vs 3392 +/‐ 293 ng ml‐1 h respectively). Half‐life values were similar on both occasions. The binding of prednisolone to serum proteins was markedly impaired during the active phase as compared to the remission. Free fraction values correlated positively with total drug concentration. A negative correlation between free fraction and serum albumin level was found during the active phase. Free prednisolone levels during the active phase did not differ significantly from those observed during remission (AUC: 937 +/‐ 128 vs 847 +/‐ 81 ng ml‐1 h respectively). These data indicate that pharmacokinetic changes are unlikely to be responsible for alterations in steroid responsiveness in nephrotic patients with hypoalbuminaemia. 1984 The British Pharmacological Society

Original languageEnglish
Pages (from-to)423-431
Number of pages9
JournalBritish Journal of Clinical Pharmacology
Volume17
Issue number4
DOIs
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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