Pharmacokinetics of theobromine and its metabolites in rabbits

Gian Luigi Traina, Maurizio Bonati

Research output: Contribution to journalArticlepeer-review


The pharmacokinetics of theobromine (3, 7-DMX) and its metabolites was investigated in detail in four male rabbits after bolus intravenous injection (4 mg/kg) of the compound. Apparent first-order rate constants for the metabolic processes involved in the formation of 3,7-DMX metabolites and their excretion in urine were calculated. Theobromine, 7-methylxanthine (7-MX) and 3-methylxanthine (3-MX) were measured in blood and urine, and the other metabolites were determined only in urine. An appropriate model of 14 compartments is formulated to describe the disposition of 3,7-DMX and its metabolites.

Original languageEnglish
Pages (from-to)41-53
Number of pages13
JournalJournal of Pharmacokinetics and Biopharmaceutics
Issue number1
Publication statusPublished - Feb 1985


  • metabolism
  • pharmacokinetics
  • rabbit
  • theobromine
  • urinary data

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)


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