Pharmacokinetics of theobromine and its metabolites in rabbits

Gian Luigi Traina, Maurizio Bonati

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The pharmacokinetics of theobromine (3, 7-DMX) and its metabolites was investigated in detail in four male rabbits after bolus intravenous injection (4 mg/kg) of the compound. Apparent first-order rate constants for the metabolic processes involved in the formation of 3,7-DMX metabolites and their excretion in urine were calculated. Theobromine, 7-methylxanthine (7-MX) and 3-methylxanthine (3-MX) were measured in blood and urine, and the other metabolites were determined only in urine. An appropriate model of 14 compartments is formulated to describe the disposition of 3,7-DMX and its metabolites.

Original languageEnglish
Pages (from-to)41-53
Number of pages13
JournalJournal of Pharmacokinetics and Biopharmaceutics
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 1985

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Theobromine
Pharmacokinetics
Urine
Rabbits
Intravenous Injections

Keywords

  • metabolism
  • pharmacokinetics
  • rabbit
  • theobromine
  • urinary data

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Pharmacokinetics of theobromine and its metabolites in rabbits. / Traina, Gian Luigi; Bonati, Maurizio.

In: Journal of Pharmacokinetics and Biopharmaceutics, Vol. 13, No. 1, 02.1985, p. 41-53.

Research output: Contribution to journalArticle

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