Abstract
The pharmacokinetics of theophylline (1,3-DMX) and its metabolites were investigated in detail in four male rabbits after bolus intravenous injection (12 mg/kg) of the compound. Theophylline was measured in blood and urine, and its metabolites were determined only in urine. Apparent first-order rate constants for the metabolic processes involved in the formation of 1,3-DMX metabolites and their excretion in urine were calculated. An appropriate 13-compartment model was formulated to describe the disposition of 1,3-DMX and its metabolites.
| Original language | English |
|---|---|
| Pages (from-to) | 279-288 |
| Number of pages | 10 |
| Journal | European Journal of Drug Metabolism and Pharmacokinetics |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 1985 |
Keywords
- metabolism
- pharmacokinetics
- rabbit
- Theophylline
- urinary data
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
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Cite this
Celardo, A., Traina, G. L., Jankowski, A., & Bonati, M. (1985). Pharmacokinetics of theophylline and its metabolites in rabbits. European Journal of Drug Metabolism and Pharmacokinetics, 10(4), 279-288. https://doi.org/10.1007/BF03189755