Pharmacokinetics of theophylline and its metabolites in rabbits

A. Celardo; G. L. Traina; A. Jankowski; M. Bonati

doi:10.1007/BF03189755

Pharmacokinetics of theophylline and its metabolites in rabbits

A. Celardo, G. L. Traina, A. Jankowski, M. Bonati

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The pharmacokinetics of theophylline (1,3-DMX) and its metabolites were investigated in detail in four male rabbits after bolus intravenous injection (12 mg/kg) of the compound. Theophylline was measured in blood and urine, and its metabolites were determined only in urine. Apparent first-order rate constants for the metabolic processes involved in the formation of 1,3-DMX metabolites and their excretion in urine were calculated. An appropriate 13-compartment model was formulated to describe the disposition of 1,3-DMX and its metabolites.

Original language	English
Pages (from-to)	279-288
Number of pages	10
Journal	European Journal of Drug Metabolism and Pharmacokinetics
Volume	10
Issue number	4
DOIs	https://doi.org/10.1007/BF03189755
Publication status	Published - Oct 1985

Keywords

metabolism
pharmacokinetics
rabbit
Theophylline
urinary data

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1007/BF03189755

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abstract = "The pharmacokinetics of theophylline (1,3-DMX) and its metabolites were investigated in detail in four male rabbits after bolus intravenous injection (12 mg/kg) of the compound. Theophylline was measured in blood and urine, and its metabolites were determined only in urine. Apparent first-order rate constants for the metabolic processes involved in the formation of 1,3-DMX metabolites and their excretion in urine were calculated. An appropriate 13-compartment model was formulated to describe the disposition of 1,3-DMX and its metabolites.",

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AU - Celardo, A.

AU - Traina, G. L.

AU - Jankowski, A.

AU - Bonati, M.

PY - 1985/10

Y1 - 1985/10

N2 - The pharmacokinetics of theophylline (1,3-DMX) and its metabolites were investigated in detail in four male rabbits after bolus intravenous injection (12 mg/kg) of the compound. Theophylline was measured in blood and urine, and its metabolites were determined only in urine. Apparent first-order rate constants for the metabolic processes involved in the formation of 1,3-DMX metabolites and their excretion in urine were calculated. An appropriate 13-compartment model was formulated to describe the disposition of 1,3-DMX and its metabolites.

AB - The pharmacokinetics of theophylline (1,3-DMX) and its metabolites were investigated in detail in four male rabbits after bolus intravenous injection (12 mg/kg) of the compound. Theophylline was measured in blood and urine, and its metabolites were determined only in urine. Apparent first-order rate constants for the metabolic processes involved in the formation of 1,3-DMX metabolites and their excretion in urine were calculated. An appropriate 13-compartment model was formulated to describe the disposition of 1,3-DMX and its metabolites.

KW - metabolism

KW - pharmacokinetics

KW - rabbit

KW - Theophylline

KW - urinary data

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JO - European Journal of Drug Metabolism and Pharmacokinetics

JF - European Journal of Drug Metabolism and Pharmacokinetics

SN - 0378-7966

IS - 4

ER -

Pharmacokinetics of theophylline and its metabolites in rabbits

Abstract

Keywords

ASJC Scopus subject areas

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