Pharmacokinetics of theophylline and its metabolites in rabbits

A. Celardo, G. L. Traina, A. Jankowski, M. Bonati

Research output: Contribution to journalArticle

Abstract

The pharmacokinetics of theophylline (1,3-DMX) and its metabolites were investigated in detail in four male rabbits after bolus intravenous injection (12 mg/kg) of the compound. Theophylline was measured in blood and urine, and its metabolites were determined only in urine. Apparent first-order rate constants for the metabolic processes involved in the formation of 1,3-DMX metabolites and their excretion in urine were calculated. An appropriate 13-compartment model was formulated to describe the disposition of 1,3-DMX and its metabolites.

Original languageEnglish
Pages (from-to)279-288
Number of pages10
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume10
Issue number4
DOIs
Publication statusPublished - Oct 1985

Keywords

  • metabolism
  • pharmacokinetics
  • rabbit
  • Theophylline
  • urinary data

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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