Abstract
Brain distribution and various pharmacological effects of clobazam and diazepam were studied in rats. When given at 10 mg/kg i.p. the compounds reached peak brain levels 15 min after injection, and showed similar half lives. At peak time brain levels were proportional to the dose administered. Very little of the N-desmethylmetabolite of each compound was found in the brain. Clobazam was less effective than diazepam in protecting rats from pentetrazol convulsions, disrupting rota-rod performance and increasing punished responses in a 'conflict' test, the relative potencies ranging from 4 to 8 in the various tests. The results are discussed in relation to the importance of animal species selection for predicting favourable therapeutic effects in humans.
| Original language | English |
|---|---|
| Pages (from-to) | 275-283 |
| Number of pages | 9 |
| Journal | Archives Internationales de Pharmacodynamie et de Therapie |
| Volume | 243 |
| Issue number | 2 |
| Publication status | Published - 1980 |
ASJC Scopus subject areas
- Pharmacology