Pharmacological and clinical applications of natriuretic peptides: Accepted knowledges or changing views?

Izzi Valerio, Chiurchiù Valerio, Baldini P. Morena

Research output: Contribution to journalArticle

Abstract

Natriuretic peptides (NPs) are endegenous low molecular weight peptides known for their hypotensive activities. Due to their ability to induce both natriuresis (Na+ secretion) and diuresis, in fact, these peptides can profoundly decrease the body haemodynamic load, an effect which represents a main goal for all therapies aiming at improving the health of those subjects affected by different forms of heart and kidney failure. Over the years, many evidences have been provided for the involvement of NPs in the control of different cardiovascular parameters both in physiological and pathological conditions, This has led many researchers to test the possible therapeutic effects of different NPs and the pharmacological industries to develop exogenous NPs forms with a higher activity. This review aims then at summarizing the current knowledge about the therapeutic and clinical applications of NPs, also considering "atypical" NPs and the problems yet to be solved.

Original languageEnglish
Pages (from-to)195-204
Number of pages10
JournalCurrent Pharmaceutical Analysis
Volume3
Issue number3
DOIs
Publication statusPublished - Aug 2007

Keywords

  • C-type Natriuretic Peptide
  • Congestive heart failure
  • Dendroaspis Natriuretic Peptide
  • Neutral endopeptidase 24.11
  • NPPB gene

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Medicine
  • Pharmaceutical Science

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