Pharmacological characterization of D1 and D2 dopamine receptors in rat limbocortical areas. II. Dorsal hippocampus

Mariagrazia Grilli, Enzo Nisoli, Maurizio Memo, Cristina Missale, PierFranco Spano

Research output: Contribution to journalArticle

Abstract

The mesolimbocortical dopamine (DA) system innervates several brain regions including the hippocampus. The aim of the present study was both to identify and to pharmacologically characterize the DA receptors located in this brain area. The results show that different agonists for D1 DA receptors, such as DA itself, SKF 82526 and (-)-apomorphine, were able to increase adenylate cyclase activity, and these effects were antagonized by haloperidol and SCH 23390. Moreover bromocriptine, lisuride and RU 24213, which are agonists for D2 DA receptors, inhibited the cyclic AMP generating system and these effects were prevented by (-)-sulpiride. According to the paradigm that D1 DA receptors are linked with adenylate cyclase in a stimulatory way, while D2 DA receptors are linked with the same enzyme in an inhibitory way, our results indicate the presence of both D1 and D2 receptors in rat hippocampus. Localization studies show that both DA receptor subtypes are restricted to the dorsal part of the hippocampus.

Original languageEnglish
Pages (from-to)253-258
Number of pages6
JournalNeuroscience Letters
Volume87
Issue number3
DOIs
Publication statusPublished - May 3 1988

Fingerprint

Dopamine D1 Receptors
Dopamine D2 Receptors
Hippocampus
Dopamine Receptors
Pharmacology
Adenylyl Cyclases
Dopamine
Fenoldopam
Lisuride
Sulpiride
Bromocriptine
Apomorphine
Brain
Haloperidol
Cyclic AMP
Enzymes

Keywords

  • Adenylate cyclase
  • Dopamine receptor
  • Dorsal hippocampus
  • Mesolimbocortical system
  • Neuroleptic
  • SKF 82526

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pharmacological characterization of D1 and D2 dopamine receptors in rat limbocortical areas. II. Dorsal hippocampus. / Grilli, Mariagrazia; Nisoli, Enzo; Memo, Maurizio; Missale, Cristina; Spano, PierFranco.

In: Neuroscience Letters, Vol. 87, No. 3, 03.05.1988, p. 253-258.

Research output: Contribution to journalArticle

Grilli, Mariagrazia ; Nisoli, Enzo ; Memo, Maurizio ; Missale, Cristina ; Spano, PierFranco. / Pharmacological characterization of D1 and D2 dopamine receptors in rat limbocortical areas. II. Dorsal hippocampus. In: Neuroscience Letters. 1988 ; Vol. 87, No. 3. pp. 253-258.
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