Pharmacological characterization of serotonin receptors involved in the control of prolactin secretion

Gianfranco Di Renzo, Salvatore Amoroso, Maurizio Taglialatela, Lorella Canzoniero, Vincenzo Basile, Alessandro Fatatis, Lucio Annunziato

Research output: Contribution to journalArticle

Abstract

The present study was undertaken to characterize the type of serotonin (5-HT) receptors involved in the control of prolactin (PRL) secretion in male rats. d-Fenfluramine (10 mg/kg i.p.), a potent 5-HT releaser and quipazine, (20 mg/kg i.p.) a 5-HT agonist, caused a marked increase in serum PRL levels. Ritanserin (200 μg/kg i.p.), a specific antagonist of 5-HT2 receptors, administered 1 h before the administration of d-fenfluramine or quipazine, completely prevented the PRL-releasing effect of these drugs. Furthermore, the administration of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH DPAT) (1.5, 3 and 6 mg/kg i.p.), a compound considered to be a prototypical 5-HT1A agonist, failed to induce any change in serum PRL levels. The same lack of effect on PRL secretion was observed after the administration which has been shown to possess a higher selectivity for 5-HT1B receptor subtypes than for 5-HT1A subtypes. These results suggest that 5-HT receptors involved in the control of PRL secretion are of the 5-HT2 type.

Original languageEnglish
Pages (from-to)371-373
Number of pages3
JournalEuropean Journal of Pharmacology
Volume162
Issue number2
DOIs
Publication statusPublished - Mar 21 1989

Keywords

  • 5-HT receptors
  • Prolactin
  • Quipazine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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