Pharmacological evidence of muscarinic-cholinergic sensitization following chronic stress

C. Orsini, C. Castellano, S. Cabib

Research output: Contribution to journalArticlepeer-review

Abstract

Rationale: Although much evidence supports a major role of brain cholinergic transmission in memory consolidation processes, little is known about cholinergic functioning under environmental pressure. Objectives: The present experiments were aimed at investigating possible functional adaptation of muscarinic receptors promoted by a chronic stressful procedure in an inbred strain of mice highly susceptible to stress. Methods: We tested the effects of post-trial administration of a cholinergic agonist and a muscarinic antagonist on the retention of a passive avoidance task in control animals and compared these effects with those observed following food restriction. Results: Food restriction enhanced the facilitatory effects of oxotremorine and reduced the impairing effects of atropine on memory consolidation. Conclusion: Our results support the view that chronic sensitization of muscarinic receptors occurs following chronic stress.

Original languageEnglish
Pages (from-to)144-147
Number of pages4
JournalPsychopharmacology
Volume155
Issue number2
DOIs
Publication statusPublished - 2001

Keywords

  • Acetylcholine
  • Animal models
  • Aversive context
  • Dopamine
  • Food restriction
  • Memory
  • Mice

ASJC Scopus subject areas

  • Pharmacology

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