Abstract
Rationale: Although much evidence supports a major role of brain cholinergic transmission in memory consolidation processes, little is known about cholinergic functioning under environmental pressure. Objectives: The present experiments were aimed at investigating possible functional adaptation of muscarinic receptors promoted by a chronic stressful procedure in an inbred strain of mice highly susceptible to stress. Methods: We tested the effects of post-trial administration of a cholinergic agonist and a muscarinic antagonist on the retention of a passive avoidance task in control animals and compared these effects with those observed following food restriction. Results: Food restriction enhanced the facilitatory effects of oxotremorine and reduced the impairing effects of atropine on memory consolidation. Conclusion: Our results support the view that chronic sensitization of muscarinic receptors occurs following chronic stress.
| Original language | English |
|---|---|
| Pages (from-to) | 144-147 |
| Number of pages | 4 |
| Journal | Psychopharmacology |
| Volume | 155 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2001 |
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Keywords
- Acetylcholine
- Animal models
- Aversive context
- Dopamine
- Food restriction
- Memory
- Mice
ASJC Scopus subject areas
- Pharmacology
Cite this
Pharmacological evidence of muscarinic-cholinergic sensitization following chronic stress. / Orsini, C.; Castellano, C.; Cabib, S.
In: Psychopharmacology, Vol. 155, No. 2, 2001, p. 144-147.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacological evidence of muscarinic-cholinergic sensitization following chronic stress
AU - Orsini, C.
AU - Castellano, C.
AU - Cabib, S.
PY - 2001
Y1 - 2001
N2 - Rationale: Although much evidence supports a major role of brain cholinergic transmission in memory consolidation processes, little is known about cholinergic functioning under environmental pressure. Objectives: The present experiments were aimed at investigating possible functional adaptation of muscarinic receptors promoted by a chronic stressful procedure in an inbred strain of mice highly susceptible to stress. Methods: We tested the effects of post-trial administration of a cholinergic agonist and a muscarinic antagonist on the retention of a passive avoidance task in control animals and compared these effects with those observed following food restriction. Results: Food restriction enhanced the facilitatory effects of oxotremorine and reduced the impairing effects of atropine on memory consolidation. Conclusion: Our results support the view that chronic sensitization of muscarinic receptors occurs following chronic stress.
AB - Rationale: Although much evidence supports a major role of brain cholinergic transmission in memory consolidation processes, little is known about cholinergic functioning under environmental pressure. Objectives: The present experiments were aimed at investigating possible functional adaptation of muscarinic receptors promoted by a chronic stressful procedure in an inbred strain of mice highly susceptible to stress. Methods: We tested the effects of post-trial administration of a cholinergic agonist and a muscarinic antagonist on the retention of a passive avoidance task in control animals and compared these effects with those observed following food restriction. Results: Food restriction enhanced the facilitatory effects of oxotremorine and reduced the impairing effects of atropine on memory consolidation. Conclusion: Our results support the view that chronic sensitization of muscarinic receptors occurs following chronic stress.
KW - Acetylcholine
KW - Animal models
KW - Aversive context
KW - Dopamine
KW - Food restriction
KW - Memory
KW - Mice
UR - http://www.scopus.com/inward/record.url?scp=0035023249&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035023249&partnerID=8YFLogxK
U2 - 10.1007/s002130100690
DO - 10.1007/s002130100690
M3 - Article
C2 - 11401002
AN - SCOPUS:0035023249
VL - 155
SP - 144
EP - 147
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 2
ER -