TY - JOUR
T1 - Pharmacological evidence of supersensitivity of central serotonergic receptors involved in the control of prolactin secretion
AU - Quattrone, Aldo
AU - Schettini, Gennaro
AU - Annunziato, Lucio
AU - Di Renzo, Gianfranco
PY - 1981/11/19
Y1 - 1981/11/19
N2 - m-Chlorophenylpiperazine (m-CPP), a serotonin receptor agonist, induced dose-related increases in plasma prolactin levels in the rat. This effect was significantly prevented by pretreatment with metergoline, a serotonin receptor blocker. Long-term degeneration of hypothalamic serotonin nerve endings induced by intraventricular injection of 5,7-dihydroxytryptamine, significantly enhanced the PRL-releasing action of m-CPP, as revealed by the shift to the left in the dose-response curve that relates the dose of m-CPP to plasma PRL levels. Thus the evidence suggests the possible development of supersensitivity of central serotonin receptors involved in the control of prolactin release.
AB - m-Chlorophenylpiperazine (m-CPP), a serotonin receptor agonist, induced dose-related increases in plasma prolactin levels in the rat. This effect was significantly prevented by pretreatment with metergoline, a serotonin receptor blocker. Long-term degeneration of hypothalamic serotonin nerve endings induced by intraventricular injection of 5,7-dihydroxytryptamine, significantly enhanced the PRL-releasing action of m-CPP, as revealed by the shift to the left in the dose-response curve that relates the dose of m-CPP to plasma PRL levels. Thus the evidence suggests the possible development of supersensitivity of central serotonin receptors involved in the control of prolactin release.
KW - m-Chlorophenylpiperazine
KW - Prolactin
KW - Serotonin
KW - Supersensitivity
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U2 - 10.1016/0014-2999(81)90003-0
DO - 10.1016/0014-2999(81)90003-0
M3 - Article
C2 - 7318925
AN - SCOPUS:0019834458
VL - 76
SP - 9
EP - 13
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -