Pharmacological evidence of supersensitivity of central serotonergic receptors involved in the control of prolactin secretion

Aldo Quattrone, Gennaro Schettini, Lucio Annunziato, Gianfranco Di Renzo

Research output: Contribution to journalArticlepeer-review

Abstract

m-Chlorophenylpiperazine (m-CPP), a serotonin receptor agonist, induced dose-related increases in plasma prolactin levels in the rat. This effect was significantly prevented by pretreatment with metergoline, a serotonin receptor blocker. Long-term degeneration of hypothalamic serotonin nerve endings induced by intraventricular injection of 5,7-dihydroxytryptamine, significantly enhanced the PRL-releasing action of m-CPP, as revealed by the shift to the left in the dose-response curve that relates the dose of m-CPP to plasma PRL levels. Thus the evidence suggests the possible development of supersensitivity of central serotonin receptors involved in the control of prolactin release.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalEuropean Journal of Pharmacology
Volume76
Issue number1
DOIs
Publication statusPublished - Nov 19 1981

Keywords

  • m-Chlorophenylpiperazine
  • Prolactin
  • Serotonin
  • Supersensitivity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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