Pharmacological Management of Erectile Dysfunction

Francesco Montorsi, Giorgio Guazzoni, Patrizio Rigatti, Guido Pozza

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Pharmacological treatment of erectile dysfunction includes all therapeutic modalities based on the use of erectogenic drugs, regardless of the route of administration. Intracavernous vasoactive injection therapy is the most commonly used treatment for erectile dysfunction. Most patients respond to intracavernous injection of either single or multiple vasoactive drugs. Major adverse effects related to this treatment include priapism, corporeal pain and the formation of nodules or plaques in the corpora cavernosa. Oral administration of drugs aimed at improving erectile function has not produced results comparable with those obtained with intracavernous injection therapy. However, in patients with psychogenic or mild organic impotence, oral treatment with drugs that influence either central or peripheral pathways controlling erection may improve erectile function. Topical administration of vasoactive drugs in the form of gels, liquid solutions or plasters is another attractive alternative for the treatment of psychogenic and mild organic erectile dysfunction. Although the ideal drug for the treatment of erectile dysfunction has not yet been identified, extensive laboratory and clinical research is ongoing and successful results are expected in the near future.

Original languageEnglish
Pages (from-to)465-479
Number of pages15
JournalDrugs
Volume50
Issue number3
DOIs
Publication statusPublished - 1995

Fingerprint

Erectile Dysfunction
Pharmacology
Pharmaceutical Preparations
Therapeutics
Plaster
Injections
Drug Administration Routes
Priapism
Topical Administration
Gels
Oral Administration
Liquids
Pain
Research

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Pharmacological Management of Erectile Dysfunction. / Montorsi, Francesco; Guazzoni, Giorgio; Rigatti, Patrizio; Pozza, Guido.

In: Drugs, Vol. 50, No. 3, 1995, p. 465-479.

Research output: Contribution to journalArticle

Montorsi, F, Guazzoni, G, Rigatti, P & Pozza, G 1995, 'Pharmacological Management of Erectile Dysfunction', Drugs, vol. 50, no. 3, pp. 465-479. https://doi.org/10.2165/00003495-199550030-00005
Montorsi, Francesco ; Guazzoni, Giorgio ; Rigatti, Patrizio ; Pozza, Guido. / Pharmacological Management of Erectile Dysfunction. In: Drugs. 1995 ; Vol. 50, No. 3. pp. 465-479.
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