Pharmacological modulation of caspase-8 in thymus-related medical conditions

Nicola Pozzesi, Alessandra Fierabracci, Trinh Thy Thuy, Maria Paola Martelli, Anna Marina Liberati, Emira Ayroldi, Carlo Riccardi, Domenico V. Delfino

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The thymus is a lymphoid organ that governs the development of a diverse T-cell repertoire capable of defending against nonselfantigens and avoiding autoimmunity. However, the thymus can also succumb to different diseases. Hypertrophic diseases, such as thymomas, are typically associated with impairment of negative selection, which leads to autoimmune disease, or disruption of positive selection, which results in immunodeficiency. Hypotrophic diseases of the thymus can manifest during acute infections, cancer, allogeneic bonemarrow transplantation, orwith aging. This condition leads to decreased immune function and can be treated by either replacing lost thymic tissue or by preventing thymic tissue death. Studies have demonstrated the critical role of caspase-8 in regulating apoptosis in the thymus. In this review, we discuss how pharmacological activation and inhibition of caspase-8 can be used to treat hypertrophic and hypotrophic diseases of the thymus, respectively, to improve its function. Copyright

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume351
Issue number1
DOIs
Publication statusPublished - Oct 1 2014

Fingerprint

Caspase 8
Thymus Gland
Pharmacology
Thymoma
Homologous Transplantation
Autoimmunity
Autoimmune Diseases
Apoptosis
T-Lymphocytes
Infection
Neoplasms

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine
  • Medicine(all)

Cite this

Pharmacological modulation of caspase-8 in thymus-related medical conditions. / Pozzesi, Nicola; Fierabracci, Alessandra; Thuy, Trinh Thy; Martelli, Maria Paola; Liberati, Anna Marina; Ayroldi, Emira; Riccardi, Carlo; Delfino, Domenico V.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 351, No. 1, 01.10.2014, p. 18-24.

Research output: Contribution to journalArticle

Pozzesi, N, Fierabracci, A, Thuy, TT, Martelli, MP, Liberati, AM, Ayroldi, E, Riccardi, C & Delfino, DV 2014, 'Pharmacological modulation of caspase-8 in thymus-related medical conditions', Journal of Pharmacology and Experimental Therapeutics, vol. 351, no. 1, pp. 18-24. https://doi.org/10.1124/jpet.114.216572
Pozzesi, Nicola ; Fierabracci, Alessandra ; Thuy, Trinh Thy ; Martelli, Maria Paola ; Liberati, Anna Marina ; Ayroldi, Emira ; Riccardi, Carlo ; Delfino, Domenico V. / Pharmacological modulation of caspase-8 in thymus-related medical conditions. In: Journal of Pharmacology and Experimental Therapeutics. 2014 ; Vol. 351, No. 1. pp. 18-24.
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