Pharmacological modulation of monocytes and macrophages

Alberto Mantovani, Annunciata Vecchi, Paola Allavena

Research output: Contribution to journalArticlepeer-review

Abstract

Mononuclear phagocytes are major players in diverse pathological conditions which include chronic inflammatory diseases, infection, autoimmunity, atherosclerosis, metabolic disorders, and cancer. Plasticity is a fundamental property of cells of the monocyte-macrophage lineage and a variety of modulators profoundly affect monocytes and macrophages. Tumor-associated macrophages (TAMs) provide a paradigm for macrophage plasticity and anticancer therapeutic modalities (chemotherapy, radiotherapy, and immunotherapy) profoundly affect their function. The development of innovative strategies targeting cells of the monocyte-macrophage lineage may pave the way to innovative therapies for a wide range of diseases.

Original languageEnglish
Pages (from-to)38-44
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume17
Issue number1
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Medicine(all)

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