Pharmacological modulation, preclinical studies, and new clinical features of myocardial ischemic preconditioning

Claudio Napoli, Aldo Pinto, Giuseppe Cirino

Research output: Contribution to journalArticle

Abstract

The term "ischemic preconditioning (PC)" was first applied to canine myocardium subjected to brief episodes of ischemia and reperfusion that tolerated a more prolonged episode of ischemia better than myocardium not previously exposed to ischemia. Protective effect of myocardial ischemic PC was demonstrated in several animal species, resulting in the strongest endogenous form of protection against myocardial injury, jeopardized myocardium, infarct size, and arrhythmias other than early reperfusion. New onset angina before acute myocardial infarction, episodes of myocardial ischemia during coronary angioplasty or bypass surgery, and the "warm-up" phenomenon may represent clinical counterparts of the PC phenomenon in humans. Here, we have attempted to summarize pharmacological modulation, preclinical studies, and new clinical features of ischemic PC. To date, the pathophysiological basis of the "chemical PC" is still not well established, and "putting PC in a bottle" for clinical applications still remains a new pharmacological venture.

Original languageEnglish
Pages (from-to)311-331
Number of pages21
JournalPharmacology and Therapeutics
Volume88
Issue number3
DOIs
Publication statusPublished - 2000

Keywords

  • Adenosine
  • Ischemic preconditioning
  • K channels
  • Myocardial ischemia
  • Oxygen radicals
  • Pharmacology

ASJC Scopus subject areas

  • Pharmacology

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