Pharmacological prophylaxis of epilepsy in neurosurgery

A. De Santis, P. Rampini, L. Ravagnati, M. Caroli, N. Grimoldi, V. A. Sironi

Research output: Chapter in Book/Report/Conference proceedingChapter


We present the results of a survey conducted among board certified Italian Neurosugeons affiliated to the Italian Society of Neurosurgery concerning their attitudes towards pharmacological prophylaxis of epilepsy in head injured patients or in patients submitted or who have to be submitted to surgery for intracranial lesions. 450 questionnaires have been sent and 136 (30.2%) neurosurgeons have already replied. The vast majority has answered all the questions. Prophylaxis has been considered useful by 90% of the neurosurgeons. Among head injured patients prophylaxis is considered and indicated mainly for patients with focal brain lesions but also for many other intracranial lesions. For supratentorial non-traumatic brain lesions (tumors, abscesses, AVM, intraparenchymal haematomas) 89% of the surgeons consider prophylaxis indicated with only minor differences for the diverse lesions. Only 14% consider prophylaxis indicated for infratentorial lesions. The majority considers phenobarbital as the first choice drug, and use monotherapy in therapeutic dose. There are differing opinions about the duration of drug treatment and the relative value of EEG, CT and MRI in decision making. Only 9.5% of the neurosurgeons do not use prophylaxis. The main reason of this choice is that they do not consider it is reasonable to treat patients who do not present seizures.

Original languageEnglish
Title of host publicationBollettino - Lega Italiana contro l'Epilessia
Number of pages2
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Pharmacological prophylaxis of epilepsy in neurosurgery'. Together they form a unique fingerprint.

Cite this