Pharmacological treatment of alcohol use disorder. Scientific evidence

Interdisciplinary Study Group CRARL - SITAC - SIPaD - SITD - SIPDip, Simone Macri, Giovanni Laviola, Rosanna Mancinelli

Research output: Contribution to journalArticlepeer-review


Pharmacological treatment of alcohol use disorder represents an essential core of the therapeutic project in a multidisciplinary approach. While non-drug treatment is evolving, from a medical perspective few pharmacotherapies are available; in particular acamprosate, naltrexone and more recently nalmefene among anticraving drugs, disulfiram as an antidipsotropic medication. New studies are focusing on off-label drugs. Moreover, scientific evidence has to support any therapeutic indication which should be tailored on patient needs and comorbidity by considering the individual bio-psycho-social profile. Follow-up is essential in order to assess patient compliance to treatment and monitoring outcomes.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalRivista di Psichiatria
Issue number3
Publication statusPublished - Jun 19 2018


  • Acamprosate/therapeutic use
  • Alcohol Deterrents/therapeutic use
  • Alcoholism/drug therapy
  • Baclofen/therapeutic use
  • Disulfiram/therapeutic use
  • Drug Evaluation
  • Humans
  • Naltrexone/analogs & derivatives
  • Off-Label Use
  • Olanzapine/therapeutic use
  • Ondansetron/therapeutic use
  • Sertraline/therapeutic use
  • Sodium Oxybate/therapeutic use
  • Topiramate/therapeutic use
  • Varenicline/therapeutic use


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