Pharmacological treatment of spondyloarthritis: Exploring the effectiveness of nonsteroidal anti-inflammatory drugs, traditional disease-modifying antirheumatic drugs and biological therapies

Francesco Caso, Luisa Costa, Antonio Del Puente, Raffaele Scarpa, Matteo Nicola Dario Minno, Gelsy Lupoli, Rosario Peluso

Research output: Contribution to journalReview articlepeer-review

Abstract

Spondyloarthritis represents a heterogeneous group of articular inflammatory diseases that share common genetic, clinical and radiological features. The therapy target of spondyloarthritis relies mainly in improving patients’ quality of life, controlling articular inflammation, preventing the structural joints damage and preserving the functional abilities, autonomy and social participation of patients. Among these, traditional disease-modifying antirheumatic drugs have been demonstrated to be effective in the management of peripheral arthritis; moreover, in the last decade, biological therapies have improved the approach to spondyloarthritis. In patients with axial spondyloarthritis, tumor necrosis factor α inhibitors are currently the only effective therapy in patients for whom conventional therapy with nonsteroidal anti-inflammatory drugs has failed. The aim of this review is to summarize the current experience and evidence about the pharmacological approach in spondyloarthritis patients.

Original languageEnglish
Pages (from-to)328-338
Number of pages11
JournalTherapeutic Advances in Chronic Disease
Volume6
Issue number6
DOIs
Publication statusPublished - 2015

Keywords

  • Biological therapies
  • Nonsteroidal anti-inflammatory drugs
  • Spondyloarthritis

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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