PHARMACOLOGIE DU CONTROLE DE LA PRISE ALIMENTAIRE

R. Samanin, S. Garattini

Research output: Contribution to journalArticle

Abstract

We have attempted to provide a progress report on current research on the role of catecholmines and serotonin receptor subtypes in feeding control. Recent evidence suggests that only some of the several catecholamine receptor subtypes are specifically involved in feeding control. They include the β1 2-adrenoceptors, the α1-adrenoceptors and the D1 dopamine receptors: stimulation of these receptors reduces feeding in rats. Stimulation of serotonergic 5-HT(1B) and 5-HT(2C) receptors reduces feeding and perhaps enhances the satiating effect of food. Recently, an interesting reciprocal relation between serotonin and cholecystokinin has been discovered in relation to feeding control. The serotonergic 5-HT(2A) receptors are involved in stress-induced anorexia and regulate the hyperphagia induced by neuropepetide Y in the nucleus paraventricularis of the hypothalamus. Both effects may involve changes in the secretion of corticotropin-releasing factor. These findings may help elaborate neuronal models of feeding control and perhaps facilitate progress in the pharmacotherapy of human obesity and eating disorders.

Original languageEnglish
Pages (from-to)107-115
Number of pages9
JournalTherapie
Volume51
Issue number2
Publication statusPublished - Mar 1996

Keywords

  • Catecholamine receptor subtypes
  • cholecystokinin
  • feeding
  • neuropeptide Y
  • rat
  • serotonergic receptor subtypes

ASJC Scopus subject areas

  • Pharmacology (medical)

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