Pharmacology on microfluidics: Multimodal analysis for studying cell-cell interaction

Emmanuel Delamarche, Noemi Tonna, Robert D. Lovchik, Fabio Bianco, Michela Matteoli

Research output: Contribution to journalArticlepeer-review

Abstract

Understanding the mechanisms of cell-cell interaction is a key unanswered question in modern pharmacology, given crosstalk defects are at the basis of many pathologies. Microfluidics represents a valuable tool for analyzing intercellular communication mediated by transmission of soluble signals, as occurring for example between neurons and glial cells in neuroinflammation, or between tumor and surrounding cells in cancer. However, the use of microfluidics for studying cell behavior still encompasses many technical and biological challenges. In this review, a state of the art of successes, potentials and limitations of microfluidics applied to key biological questions in modern pharmacology is analyzed and commented.

Original languageEnglish
Pages (from-to)821-828
Number of pages8
JournalCurrent Opinion in Pharmacology
Volume13
Issue number5
DOIs
Publication statusPublished - Oct 2013

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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