TY - JOUR
T1 - Pharmacotherapeutic management of lower urinary tract symptoms
AU - Zanghì, Aurora
AU - Cimino, Sebastiano
AU - Urzì, Daniele
AU - Privitera, Salvatore
AU - Zagari, Francesco
AU - Lanza, Giuseppe
AU - Patti, Francesco
AU - D’Amico, Emanuele
PY - 2020
Y1 - 2020
N2 - Introduction: Multiple Sclerosis (MS) manifests with a plethora of signs and symptoms affecting brain structures and spinal pathways. The multitude of lesions in MS patients makes difficult to establish the relative role of each of them to lower urinary tract symptoms (LUTS). Generally, the subcortical white-matter lesions result in detrusor overactivity, whilst lesions of the spinal cord result in the combined occurrence of detrusor overactivity and detrusor-sphincter dyssynergia (DSD). It has been estimated that 80–90% of patients with MS will suffer from some form of LUTS over the course of the disease. Among LUTS, the most reported is detrusor overactivity which includes urinary urgency, frequent urination, nocturia, and urge urinary incontinence. Areas covered: The authors review the management of lower urinary tract symptoms in MS patients providing their expert opinions on the subject matter. Expert opinion: LUTS affect the quality of life substantially and are associated with a significantly increased mortality. The adequate management is an important challenge for both patients and caregivers with a multidisciplinary approach likely necessary.
AB - Introduction: Multiple Sclerosis (MS) manifests with a plethora of signs and symptoms affecting brain structures and spinal pathways. The multitude of lesions in MS patients makes difficult to establish the relative role of each of them to lower urinary tract symptoms (LUTS). Generally, the subcortical white-matter lesions result in detrusor overactivity, whilst lesions of the spinal cord result in the combined occurrence of detrusor overactivity and detrusor-sphincter dyssynergia (DSD). It has been estimated that 80–90% of patients with MS will suffer from some form of LUTS over the course of the disease. Among LUTS, the most reported is detrusor overactivity which includes urinary urgency, frequent urination, nocturia, and urge urinary incontinence. Areas covered: The authors review the management of lower urinary tract symptoms in MS patients providing their expert opinions on the subject matter. Expert opinion: LUTS affect the quality of life substantially and are associated with a significantly increased mortality. The adequate management is an important challenge for both patients and caregivers with a multidisciplinary approach likely necessary.
KW - multidisciplinary approach
KW - Multiple sclerosis
KW - therapeutic management
KW - urinary dysfunction
UR - http://www.scopus.com/inward/record.url?scp=85086042088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85086042088&partnerID=8YFLogxK
U2 - 10.1080/14656566.2020.1767068
DO - 10.1080/14656566.2020.1767068
M3 - Review article
C2 - 32452702
AN - SCOPUS:85086042088
JO - Expert Opinion on Pharmacotherapy
JF - Expert Opinion on Pharmacotherapy
SN - 1465-6566
ER -