Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GA2LEN platform. The Galenda project

P. J. Bousquet, P. Demoly, A. Romano, W. Aberer, A. Bircher, M. Blanca, K. Brockow, W. Pichler, M. J. Torres, I. Terreehorst, B. Arnoux, M. Atanaskovic-Markovic, A. Barbaud, A. Bijl, P. Bonadonna, P. G. Burney, S. Caimmi, G. W. Canonica, J. Cernadas, B. DahlenJ. P. Daures, J. Fernandez, E. Gomes, J. L. Gueant, M. L. Kowalski, V. Kvedariene, P. M. Mertes, P. Martins, E. Nizankowska-Mogilnicka, N. Papadopoulos, C. Ponvert, M. Pirmohamed, J. Ring, M. Salapatas, M. L. Sanz, A. Szczeklik, E. Van Ganse, A. L. De Weck, T. Zuberbier, H. F. Merk, B. Sachs, A. Sidoroff

Research output: Contribution to journalArticle

Abstract

Nonallergic hypersensitivity and allergic reactions are part of the many different types of adverse drug reactions (ADRs). Databases exist for the collection of ADRs. Spontaneous reporting makes up the core data-generating system of pharmacovigilance, but there is a large under-estimation of allergy/hypersensitivity drug reactions. A specific database is therefore required for drug allergy and hypersensitivity using standard operating procedures (SOPs), as the diagnosis of drug allergy/hypersensitivity is difficult and current pharmacovigilance algorithms are insufficient. Although difficult, the diagnosis of drug allergy/hypersensitivity has been standardized by the European Network for Drug Allergy (ENDA) under the aegis of the European Academy of Allergology and Clinical Immunology and SOPs have been published. Based on ENDA and Global Allergy and Asthma European Network (GA2LEN, EU Framework Programme 6) SOPs, a Drug Allergy and Hypersensitivity Database (DAHD®) has been established under FileMaker® Pro 9. It is already available online in many different languages and can be accessed using a personal login. GA2LEN is a European network of 27 partners (16 countries) and 59 collaborating centres (26 countries), which can coordinate and implement the DAHD across Europe. The GA2LEN-ENDA-DAHD platform interacting with a pharmacovigilance network appears to be of great interest for the reporting of allergy/hypersensitivity ADRs in conjunction with other pharmacovigilance instruments.

Original languageEnglish
Pages (from-to)194-203
Number of pages10
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume64
Issue number2
DOIs
Publication statusPublished - Feb 2009

Fingerprint

Pharmacovigilance
Drug Hypersensitivity
Databases
Hypersensitivity
Drug-Related Side Effects and Adverse Reactions

Keywords

  • DAHD
  • Database
  • Drug allergy
  • ENDA
  • GA2LEN

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GA2LEN platform. The Galenda project. / Bousquet, P. J.; Demoly, P.; Romano, A.; Aberer, W.; Bircher, A.; Blanca, M.; Brockow, K.; Pichler, W.; Torres, M. J.; Terreehorst, I.; Arnoux, B.; Atanaskovic-Markovic, M.; Barbaud, A.; Bijl, A.; Bonadonna, P.; Burney, P. G.; Caimmi, S.; Canonica, G. W.; Cernadas, J.; Dahlen, B.; Daures, J. P.; Fernandez, J.; Gomes, E.; Gueant, J. L.; Kowalski, M. L.; Kvedariene, V.; Mertes, P. M.; Martins, P.; Nizankowska-Mogilnicka, E.; Papadopoulos, N.; Ponvert, C.; Pirmohamed, M.; Ring, J.; Salapatas, M.; Sanz, M. L.; Szczeklik, A.; Van Ganse, E.; De Weck, A. L.; Zuberbier, T.; Merk, H. F.; Sachs, B.; Sidoroff, A.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 64, No. 2, 02.2009, p. 194-203.

Research output: Contribution to journalArticle

Bousquet, PJ, Demoly, P, Romano, A, Aberer, W, Bircher, A, Blanca, M, Brockow, K, Pichler, W, Torres, MJ, Terreehorst, I, Arnoux, B, Atanaskovic-Markovic, M, Barbaud, A, Bijl, A, Bonadonna, P, Burney, PG, Caimmi, S, Canonica, GW, Cernadas, J, Dahlen, B, Daures, JP, Fernandez, J, Gomes, E, Gueant, JL, Kowalski, ML, Kvedariene, V, Mertes, PM, Martins, P, Nizankowska-Mogilnicka, E, Papadopoulos, N, Ponvert, C, Pirmohamed, M, Ring, J, Salapatas, M, Sanz, ML, Szczeklik, A, Van Ganse, E, De Weck, AL, Zuberbier, T, Merk, HF, Sachs, B & Sidoroff, A 2009, 'Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GA2LEN platform. The Galenda project', Allergy: European Journal of Allergy and Clinical Immunology, vol. 64, no. 2, pp. 194-203. https://doi.org/10.1111/j.1398-9995.2008.01944.x
Bousquet, P. J. ; Demoly, P. ; Romano, A. ; Aberer, W. ; Bircher, A. ; Blanca, M. ; Brockow, K. ; Pichler, W. ; Torres, M. J. ; Terreehorst, I. ; Arnoux, B. ; Atanaskovic-Markovic, M. ; Barbaud, A. ; Bijl, A. ; Bonadonna, P. ; Burney, P. G. ; Caimmi, S. ; Canonica, G. W. ; Cernadas, J. ; Dahlen, B. ; Daures, J. P. ; Fernandez, J. ; Gomes, E. ; Gueant, J. L. ; Kowalski, M. L. ; Kvedariene, V. ; Mertes, P. M. ; Martins, P. ; Nizankowska-Mogilnicka, E. ; Papadopoulos, N. ; Ponvert, C. ; Pirmohamed, M. ; Ring, J. ; Salapatas, M. ; Sanz, M. L. ; Szczeklik, A. ; Van Ganse, E. ; De Weck, A. L. ; Zuberbier, T. ; Merk, H. F. ; Sachs, B. ; Sidoroff, A. / Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GA2LEN platform. The Galenda project. In: Allergy: European Journal of Allergy and Clinical Immunology. 2009 ; Vol. 64, No. 2. pp. 194-203.
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