Pharyngeal colonization by streptococcus pneumoniae in older children and adolescents in a geographical area characterized by relatively limited pneumococcal vaccination coverage

Nicola Principi; Leonardo Terranova; Alberto Zampiero; Valentina Montinaro; Valentina Ierardi; Walter Peves Rios; Claudio Pelucchi; Susanna Esposito

doi:10.1097/INF.0000000000000637

Pharyngeal colonization by streptococcus pneumoniae in older children and adolescents in a geographical area characterized by relatively limited pneumococcal vaccination coverage

Nicola Principi, Leonardo Terranova, Alberto Zampiero, Valentina Montinaro, Valentina Ierardi, Walter Peves Rios, Claudio Pelucchi, Susanna Esposito

Research output: Contribution to journal › Article

Abstract

Background: The aim of this study was to evaluate the relation between colonization and vaccination status with pneumococcal conjugate vaccine (PCV) in older children and adolescents living in an area characterized by relatively limited vaccination coverage. Methods: Oropharyngeal swabs were obtained from 2076 randomly selected healthy school-age children and adolescents, and the extracted genomic DNA was tested for Streptococcus pneumoniae by means of real-time polymerase chain reaction. All of the positive cases were subsequently serotyped, and the association between vaccination status with the heptavalent PCV (PCV7) and pneumococcal colonization was determined. Results: S. pneumoniae was identified in the oropharyngeal swabs of 1201 subjects (57.9%), and its prevalence declined with age (74.9% in subjects aged

Original language	English
Pages (from-to)	426-432
Number of pages	7
Journal	Pediatric Infectious Disease Journal
Volume	34
Issue number	4
DOIs	https://doi.org/10.1097/INF.0000000000000637
Publication status	Published - Apr 21 2015

Keywords

pneumococcal carrier
pneumococcal colonization
pneumococcal conjugate vaccine
pneumococcal vaccination
Streptococcus pneumoniae

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Infectious Diseases
Microbiology (medical)

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10.1097/INF.0000000000000637

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Principi, N., Terranova, L., Zampiero, A., Montinaro, V., Ierardi, V., Peves Rios, W., Pelucchi, C., & Esposito, S. (2015). Pharyngeal colonization by streptococcus pneumoniae in older children and adolescents in a geographical area characterized by relatively limited pneumococcal vaccination coverage. Pediatric Infectious Disease Journal, 34(4), 426-432. https://doi.org/10.1097/INF.0000000000000637

Pharyngeal colonization by streptococcus pneumoniae in older children and adolescents in a geographical area characterized by relatively limited pneumococcal vaccination coverage. / Principi, Nicola; Terranova, Leonardo; Zampiero, Alberto; Montinaro, Valentina; Ierardi, Valentina; Peves Rios, Walter; Pelucchi, Claudio; Esposito, Susanna.

In: Pediatric Infectious Disease Journal, Vol. 34, No. 4, 21.04.2015, p. 426-432.

Research output: Contribution to journal › Article

Principi, N, Terranova, L, Zampiero, A, Montinaro, V, Ierardi, V, Peves Rios, W, Pelucchi, C & Esposito, S 2015, 'Pharyngeal colonization by streptococcus pneumoniae in older children and adolescents in a geographical area characterized by relatively limited pneumococcal vaccination coverage', Pediatric Infectious Disease Journal, vol. 34, no. 4, pp. 426-432. https://doi.org/10.1097/INF.0000000000000637

Principi N, Terranova L, Zampiero A, Montinaro V, Ierardi V, Peves Rios W et al. Pharyngeal colonization by streptococcus pneumoniae in older children and adolescents in a geographical area characterized by relatively limited pneumococcal vaccination coverage. Pediatric Infectious Disease Journal. 2015 Apr 21;34(4):426-432. https://doi.org/10.1097/INF.0000000000000637

Principi, Nicola ; Terranova, Leonardo ; Zampiero, Alberto ; Montinaro, Valentina ; Ierardi, Valentina ; Peves Rios, Walter ; Pelucchi, Claudio ; Esposito, Susanna. / Pharyngeal colonization by streptococcus pneumoniae in older children and adolescents in a geographical area characterized by relatively limited pneumococcal vaccination coverage. In: Pediatric Infectious Disease Journal. 2015 ; Vol. 34, No. 4. pp. 426-432.

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