Abstract
Background: The aim of this study was to evaluate the relation between colonization and vaccination status with pneumococcal conjugate vaccine (PCV) in older children and adolescents living in an area characterized by relatively limited vaccination coverage. Methods: Oropharyngeal swabs were obtained from 2076 randomly selected healthy school-age children and adolescents, and the extracted genomic DNA was tested for Streptococcus pneumoniae by means of real-time polymerase chain reaction. All of the positive cases were subsequently serotyped, and the association between vaccination status with the heptavalent PCV (PCV7) and pneumococcal colonization was determined. Results: S. pneumoniae was identified in the oropharyngeal swabs of 1201 subjects (57.9%), and its prevalence declined with age (74.9% in subjects aged
| Original language | English |
|---|---|
| Pages (from-to) | 426-432 |
| Number of pages | 7 |
| Journal | Pediatric Infectious Disease Journal |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 21 2015 |
Fingerprint
Keywords
- pneumococcal carrier
- pneumococcal colonization
- pneumococcal conjugate vaccine
- pneumococcal vaccination
- Streptococcus pneumoniae
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Infectious Diseases
- Microbiology (medical)
Cite this
Pharyngeal colonization by streptococcus pneumoniae in older children and adolescents in a geographical area characterized by relatively limited pneumococcal vaccination coverage. / Principi, Nicola; Terranova, Leonardo; Zampiero, Alberto; Montinaro, Valentina; Ierardi, Valentina; Peves Rios, Walter; Pelucchi, Claudio; Esposito, Susanna.
In: Pediatric Infectious Disease Journal, Vol. 34, No. 4, 21.04.2015, p. 426-432.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharyngeal colonization by streptococcus pneumoniae in older children and adolescents in a geographical area characterized by relatively limited pneumococcal vaccination coverage
AU - Principi, Nicola
AU - Terranova, Leonardo
AU - Zampiero, Alberto
AU - Montinaro, Valentina
AU - Ierardi, Valentina
AU - Peves Rios, Walter
AU - Pelucchi, Claudio
AU - Esposito, Susanna
PY - 2015/4/21
Y1 - 2015/4/21
N2 - Background: The aim of this study was to evaluate the relation between colonization and vaccination status with pneumococcal conjugate vaccine (PCV) in older children and adolescents living in an area characterized by relatively limited vaccination coverage. Methods: Oropharyngeal swabs were obtained from 2076 randomly selected healthy school-age children and adolescents, and the extracted genomic DNA was tested for Streptococcus pneumoniae by means of real-time polymerase chain reaction. All of the positive cases were subsequently serotyped, and the association between vaccination status with the heptavalent PCV (PCV7) and pneumococcal colonization was determined. Results: S. pneumoniae was identified in the oropharyngeal swabs of 1201 subjects (57.9%), and its prevalence declined with age (74.9% in subjects aged
AB - Background: The aim of this study was to evaluate the relation between colonization and vaccination status with pneumococcal conjugate vaccine (PCV) in older children and adolescents living in an area characterized by relatively limited vaccination coverage. Methods: Oropharyngeal swabs were obtained from 2076 randomly selected healthy school-age children and adolescents, and the extracted genomic DNA was tested for Streptococcus pneumoniae by means of real-time polymerase chain reaction. All of the positive cases were subsequently serotyped, and the association between vaccination status with the heptavalent PCV (PCV7) and pneumococcal colonization was determined. Results: S. pneumoniae was identified in the oropharyngeal swabs of 1201 subjects (57.9%), and its prevalence declined with age (74.9% in subjects aged
KW - pneumococcal carrier
KW - pneumococcal colonization
KW - pneumococcal conjugate vaccine
KW - pneumococcal vaccination
KW - Streptococcus pneumoniae
UR - http://www.scopus.com/inward/record.url?scp=84937572789&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84937572789&partnerID=8YFLogxK
U2 - 10.1097/INF.0000000000000637
DO - 10.1097/INF.0000000000000637
M3 - Article
VL - 34
SP - 426
EP - 432
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
SN - 0891-3668
IS - 4
ER -