Pharyngeal colonization by streptococcus pneumoniae in older children and adolescents in a geographical area characterized by relatively limited pneumococcal vaccination coverage

Nicola Principi, Leonardo Terranova, Alberto Zampiero, Valentina Montinaro, Valentina Ierardi, Walter Peves Rios, Claudio Pelucchi, Susanna Esposito

Research output: Contribution to journalArticle

Abstract

Background: The aim of this study was to evaluate the relation between colonization and vaccination status with pneumococcal conjugate vaccine (PCV) in older children and adolescents living in an area characterized by relatively limited vaccination coverage. Methods: Oropharyngeal swabs were obtained from 2076 randomly selected healthy school-age children and adolescents, and the extracted genomic DNA was tested for Streptococcus pneumoniae by means of real-time polymerase chain reaction. All of the positive cases were subsequently serotyped, and the association between vaccination status with the heptavalent PCV (PCV7) and pneumococcal colonization was determined. Results: S. pneumoniae was identified in the oropharyngeal swabs of 1201 subjects (57.9%), and its prevalence declined with age (74.9% in subjects aged

Original languageEnglish
Pages (from-to)426-432
Number of pages7
JournalPediatric Infectious Disease Journal
Volume34
Issue number4
DOIs
Publication statusPublished - Apr 21 2015

Keywords

  • pneumococcal carrier
  • pneumococcal colonization
  • pneumococcal conjugate vaccine
  • pneumococcal vaccination
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

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