Phase I study of vinorelbine and paclitaxel in small-cell lung cancer

Rosario Vincenzo Iaffaioli, Gaetano Facchini, Anna Tortoriello, Francesco Caponigro, Alfonso Illiano, Maria Gentile, Adriano Gravina, Paolo Muto

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Vinorelbine and paclitaxel interfere with mitotic spindle function through different mechanisms of action. Both of the drugs show antitumor activity in small-cell lung cancer when used as single agents; furthermore, in vitro and in vivo studies have shown a synergistic activity between the two drugs. Patients and methods: Patients with small-cell lung cancer no longer amenable to conventional treatment were entered into a phase I study in which vinorelbine was given at a fixed dose of 30 mg/m2 by 15- min intravenous infusion, whereas paclitaxel was given by 3-h infusion starting 1 h after vinorelbine at an initial dose of 90 mg/m2, which was subsequently escalated by 30-mg/m2 steps. Cycles were repeated every 21 days. Results: Grade 3 neutropenia was observed only in three patients treated at the fifty dose level. Thrombocytopenia never reached grade 3. Neurotoxicity was considered dose-limiting, since grade 3 peripheral neuropathy occurred in three of five patients treated at the fifth dose level (paclitaxel 210 mg/m2). Other side effects were generally mild. The overall response rate in 22 evaluable patients was 32% (95% CI 13-51%); in particular, 1 complete response (45%) and 6 partial responses (273%) were observed. The maximally tolerated doses recommended for phase II studies are 180 mg/m2 for paclitaxel and 30 mg/m2 for vinorelbine. The observed myelosuppression was less severe than anticipated on the basis of the effects of each drug alone. Conclusions: The promising activity of this drug combination warrants a phase II study in untreated patients with extensive- stage small-cell lung cancer.

Original languageEnglish
Pages (from-to)86-90
Number of pages5
JournalCancer Chemotherapy and Pharmacology
Volume41
Issue number1
DOIs
Publication statusPublished - 1997

Keywords

  • Paclitaxel
  • Small-cell lung cancer
  • Vinorelbine

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology
  • Oncology

Fingerprint Dive into the research topics of 'Phase I study of vinorelbine and paclitaxel in small-cell lung cancer'. Together they form a unique fingerprint.

Cite this