Phase II study of combined immunotherapy, chemotherapy, and radiotherapy in the postoperative treatment of advanced non-small-cell lung cancer

Giovanni Battista Ratto, Mara A. Cafferata, Tindaro Scolaro, Paolo Bruzzi, Antonella Alloisio, Roberta Costa, Elisabetta Spessa, Claudia Semino, Giovanni Melioli

Research output: Contribution to journalArticlepeer-review

Abstract

The association of adoptive immunotherapy (AI) and radiotherapy has been shown to be effective in the control of residual intrathoracic disease, while having no systemic advantages, in patients operated on for locally advanced non-small-cell lung cancer (NSCLC). The potential synergy of coupling immunotherapy and chemotherapy has been emphasized in several tumors including NSCLC. The aim of this work was to determine the feasibility and activity of a combined therapeutic program, including AI, chemotherapy, and radiotherapy in patients who had undergone incomplete resections for NSCLC. In a phase II trial, 13 patients received the combined treatment. AI was given from week 4 after surgery until week 8. Concurrent chemo(cisplatin and etoposide)-radiotherapy (60 Gy) was given from week 9 to week 14. Twenty eligible patients received chemoradiotherapy only and were used as a nonrandomized concomitant group for merely descriptive purposes. At 9-month follow-up, 10 of the 13 patients had progression of disease and the study was stopped. Progression-free survival and survival were similar to those of the chemoradiotherapy group. The present study showed that the sequence of immunotherapy followed by chemotherapy is not effective as adjuvant treatment in patients operated on for stage III NSCLC, at least when used according to the adopted schedule.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalJournal of Immunotherapy
Volume23
Issue number1
DOIs
Publication statusPublished - 2000

Keywords

  • Adoptive immunotherapy
  • Chemotherapy
  • Non-small-cell lung cancer
  • Radiotherapy
  • Tumor-infiltrating lymphocytes

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology
  • Immunology

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