Phase II study of teniposide (VM-26) in multiple myeloma

U. Tirelli, V. Zagonel, A. Veronesi

Research output: Contribution to journalArticlepeer-review

Abstract

From September 1979 to December 1983, a phase II trial with teniposide (VM-26) in multiple myeloma (MM) was conducted at our institution. Of the 30 patients entered, 25 were evaluable for response, 12 previously treated with M-2 protocol and 13 previously untreated elderly (≥ 70 years) patients. A median of nine cycles (range 1-21) of VM-26 was administered. Seven responses (28%) according to Myeloma Task Force criteria were observed with a median duration of 4 months (range 2-12+). Four responses (33%) were observed in the 12 previously treated patients. Overall toxicity was mild. VM-26 seems an active drug in MM, without significant toxicity even in elderly patients.

Original languageEnglish
Pages (from-to)329-331
Number of pages3
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume8
Issue number4
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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