Phase II study of weekly carboplatin in pretreated adult malignant gliomas

Veronica Villani, Andrea Pace, Antonello Vidiri, Antonio Tanzilli, Francesca Sperati, Irene Terrenato, Carosi Mariantonia, Beatrice Casini, Giulio Metro, Marta Maschio, Koudriavtseva Tatiana, Francesco Cognetti, Alessandra Fabi

Research output: Contribution to journalArticle

Abstract

Purpose: Patients with relapse of recurrent glioma have a poor outcome and limited treatment options. The aim of this study is to investigate the clinical benefit and tolerability of weekly intravenous administration of carboplatin-based monotherapy in adult glioma patients who had progressed from previous chemotherapy lines based on temozolomide and nitrosoureas. Methods: This was a single-arm, phase II study. Eligibility criteria included progressive or recurrent glioma after radiotherapy and chemotherapy-based treatments and Karnofsky performance status (KPS) > 60. Results: Thirty-two patients (median age 43.5 years) were enrolled to receive weekly carboplatin monotherapy in an intravenous method of administration. The median duration of response was 7.3 months with an overall disease control rate of 31.3%. Median progression-free survival was 2.3 months while overall survival was 5.5 months. Pre-treatment with corticosteroids (i.e. dexamethasone) was associated to clinical benefit in 43.8% of patients. Patients achieving clinical benefit exhibited a longer progression-free survival (4.6 vs. 1.5 months; p > 0.001) and overall survival (7.9 vs. 3.2 months; p = 0.041) compared with those not achieving clinical benefit. Conclusions: Our findings show that single agent, weekly, intravenous administration of carboplatin may have a role in patients with recurrent glioma and suggest that pre-treatment with corticosteroids may confer survival benefit.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalJournal of Neuro-Oncology
Volume144
Issue number1
DOIs
Publication statusPublished - Aug 15 2019

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Keywords

  • Carboplatin
  • Corticosteroid use
  • Glioblastoma
  • Progression-free survival
  • Recurrence

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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