Phase II study on gemcitabine in recurrent and/or metastatic adenoid cystic carcinoma of the head and neck (EORTC 24982)

C. M L van Herpen, L. D. Locati, J. Buter, J. Thomas, J. Bogaerts, D. Lacombe, P. de Mulder, A. Awada, L. Licitra, J. Bernier, J. B. Vermorken

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Abstract

Background: This phase II study was conducted to determine the antitumour activity of gemcitabine in adenoid cystic carcinoma (ACC). Patients and methods: Patients with progressive and/or symptomatic, recurrent and/or metastatic ACC were treated with gemcitabine 1250 mg/m2 intravenous (i.v.) on days 1 and 8 of each 21-day cycle. Each cycle was repeated every 3 weeks in the absence of disease progression for a minimum of four cycles and a maximum of 12 cycles. Results: Among 21 ACC patients, there were no objective responses. Eleven patients had a stable disease, of which ten patients for more than 6 months, and eight had a progressive disease after 4 cycles. Gemcitabine was well tolerated by most patients. Conclusion: We conclude that gemcitabine is not an active drug in ACC.

Original languageEnglish
Pages (from-to)2542-2545
Number of pages4
JournalEuropean Journal of Cancer
Volume44
Issue number17
DOIs
Publication statusPublished - Nov 2008

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Keywords

  • Adenoid cystic carcinoma
  • Gemcitabine
  • Head and neck cancer
  • Salivary gland tumours

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

van Herpen, C. M. L., Locati, L. D., Buter, J., Thomas, J., Bogaerts, J., Lacombe, D., de Mulder, P., Awada, A., Licitra, L., Bernier, J., & Vermorken, J. B. (2008). Phase II study on gemcitabine in recurrent and/or metastatic adenoid cystic carcinoma of the head and neck (EORTC 24982). European Journal of Cancer, 44(17), 2542-2545. https://doi.org/10.1016/j.ejca.2008.08.014