Abstract
Background: Based on activity in a case report, mitoxantrone was studied in a phase II study in adenoid cystic carcinoma. Patients and methods: Patients with symptomatic and/or rapidly progressive metastatic or recurrent adenoid cystic carcinoma were eligible for this study. They were treated with mitoxantrone given intravenously by bolus injection at a dose of 14 mg/m2, cycles repeated every 3 weeks. Results: Thirty-six chemotherapy-naive patients entered on trial, 4 were ineligible. A median of 6 cycles per patient were given. Leucocytopenia (in 97% of patients) was the most important side effect and tended to be cumulative. Other side effects were mainly mild to moderate and consisted of nausea (62%), vomiting (29%), alopecia (53%) and mucositis (41%). Four of 32 patients had a partial response (12%; 95% CI 4%-29%) lasting 3-13 months, 22 patients (69%) had a stable disease. Conclusion: Mitoxantrone at this dose and schedule has modest activity in adenoid cystic carcinomas.
Original language | English |
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Pages (from-to) | 867-869 |
Number of pages | 3 |
Journal | Annals of Oncology |
Volume | 7 |
Issue number | 8 |
Publication status | Published - Oct 1996 |
Keywords
- Adenoid cystic carcinoma
- Mitoxantrone
- Phase II study
ASJC Scopus subject areas
- Oncology
- Cancer Research