Phase II study with amsacrines (m-AMSA and m-AMSA lactate) in refractory lymphomas

E. Bajetta, R. Buzzoni, S. Viviani, F. Villani, P. Piotti, G. Gasparini, G. Bonadonna

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A total of 70 patients with malignant lymphomas refractory to one or more chemotherapeutic regimens were treated with iv amsacrines (m-AMSA and m-AMSA lactate). Of 58 evaluable patients, 12 had Hodgkin's disease and 46 had non-Hodgkin's lymphoma. Twenty-nine of the evaluable patients received m-AMSA and 29 received m-AMSA lactate. The amsacrines were recycled every 3 weeks. The doses of m-AMSA were 90-120, 70, and 25-30 mg/m2/day for 3 days, respectively. All patients treated with m-AMSA lactate received a single dose of 225 mg/m2. In Hodgkin's disease, the response rate was 58.3% (one complete response among 12 patients), and in non-Hodgkin's lymphoma, the response rate was 30.4% (six complete responses among 46 patients). The median duration of response was 3 and 5 months, respectively. The response rate was unfavorably affected by the presence of extranodal disease and a Karnofsky performance status 2. This study indicates that m-AMSA and m-AMSA lactate are active and moderately toxic in previously treated malignant lymphomas. Thus, amsacrines could be effectively incorporated into salvage polydrug regimens.

Original languageEnglish
Pages (from-to)965-969
Number of pages5
JournalCancer Treatment Reports
Issue number9
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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