Phase II trial of interferon-α-2a plus psolaren with ultraviolet light A in patients with cutaneous T-cell lymphoma

Vanna Chiarion-Sileni, Antonio Bononi, Cleto Veller Fornasa, Mariella Soraru, Mauro Alaibac, Eros Ferrazzi, Roberta Redelotti, Andrea Peserico, Silvio Monfardini, Luigi Salvagno

Research output: Contribution to journalArticle

Abstract

PURPOSE. To evaluate the efficacy and side effects of psolaren with ultraviolet light A (PUVA) and interferon-alpha-2a (IFN-α-2a) in patients with mycosis fungoides (MF) and Sézary syndrome (SS). PATIENTS AND METHODS. From May 1993 to January 1999, 63 symptomatic patients with all stages of MF and SS were treated in a prospective Phase II trial with systemic escalating doses of IFN-α-2a combined with PUVA for 1 year, followed by indefinite PUVA maintenance in complete responding patients. RESULTS. Sixty-three patients were enrolled (Stage IA, n = 6; IB, n = 37; IIA, n = 3; IIB, n = 3; III, n = 12; IVA, n = 2). Ten patients had received previous therapy. The median follow-up duration for the entire cohort is 37 months. Of 63 patients, 51 achieved a complete response (CR; 74.6%) or partial response (PR; 6%) to therapy. The median response duration is 32 months. The 5-year overall survival rate is 91% and the 5-year disease-free survival rate is 75%. No life-threatening side effects were observed. Five patients stopped IFN-α-2a therapy due to toxicity. Eighty-four percent of the patients received more than 75% of the planned dose (12 million units three times a week). CONCLUSIONS. This combination of IFN-α-2a and phototherapy is an effective and safe therapy for patients with symptomatic MF.

Original languageEnglish
Pages (from-to)569-575
Number of pages7
JournalCancer
Volume95
Issue number3
DOIs
Publication statusPublished - Aug 1 2002

Keywords

  • Cutaneous T-cell lymphomas
  • IFN-α-2a
  • PUVA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Chiarion-Sileni, V., Bononi, A., Fornasa, C. V., Soraru, M., Alaibac, M., Ferrazzi, E., Redelotti, R., Peserico, A., Monfardini, S., & Salvagno, L. (2002). Phase II trial of interferon-α-2a plus psolaren with ultraviolet light A in patients with cutaneous T-cell lymphoma. Cancer, 95(3), 569-575. https://doi.org/10.1002/cncr.10706