Phase II trial of methylprednisolone pulse therapy in childhood chronic thrombocytopenia

Domenico Del Principe, Adriana Menichelli, Pier Giorgio Mori, Domenico de Mattia, Giacomo Mancuso, Vittorio Carnelli, Luigi Zanesco, Momcilo Jankovic, Michela Calmasini, Augusto Amici, Crescenzio Miano, Domenico Rosati, Giovanni Ciavarella, Gaetano Oddo, Paola Giulotto, Giuseppe Masera, Tiziana Lanza

Research output: Contribution to journalArticle

Abstract

Nineteen children with chronic idiopathic thrombocytopenia (ITP) were treated with a single intravenous injection of methylprednisolone (M P), 15 mg/kg/day, for 3 consecutive days. The 3-day pulses gave rise to a positive and fast therapeutic response with increase of the platelet count in about three quarters of the patients. The platelet count remained above 50 x 109/1 for more than 1 month in 10 children. Eight out of them still presented a safe platelet count (> 50 x 109/l) 4 months after the onset of the therapy. The MP therapy improved the platelet count more in the older children and possibly in the females. No severe side effects were observed. Our results suggest that this therapeutic approach could be useful in the management of acute bleeding episodes in children with chronic ITP.

Original languageEnglish
Pages (from-to)226-230
Number of pages5
JournalActa Haematologica
Volume77
Issue number4
DOIs
Publication statusPublished - 1987

Keywords

  • Chronic idiopathie thrombocytopenia
  • Methylprednisolone

ASJC Scopus subject areas

  • Hematology

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    Principe, D. D., Menichelli, A., Mori, P. G., de Mattia, D., Mancuso, G., Carnelli, V., Zanesco, L., Jankovic, M., Calmasini, M., Amici, A., Miano, C., Rosati, D., Ciavarella, G., Oddo, G., Giulotto, P., Masera, G., & Lanza, T. (1987). Phase II trial of methylprednisolone pulse therapy in childhood chronic thrombocytopenia. Acta Haematologica, 77(4), 226-230. https://doi.org/10.1159/000206000