Phase ii trial of mitozolomide in patients with advanced ovarian cancer: A study of the eortc gynecological cancer cooperative group

J. P. Neijt; M. E L van der Burg; J. P. Guastalla; M. George; M. Piccart; J. Vermorken; F. Carnino; N. Rotmensz

doi:10.3109/02841868909092290

Phase ii trial of mitozolomide in patients with advanced ovarian cancer: A study of the eortc gynecological cancer cooperative group

J. P. Neijt, M. E L van der Burg, J. P. Guastalla, M. George, M. Piccart, J. Vermorken, F. Carnino, N. Rotmensz

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Twenty-seven fully evaluable patients with advanced ovarian cancer and documented disease progression despite cytotoxic treatment were treated with mitozolomide (NCS-353451) 90 mg/m² as a 1-h infusion once every 6 weeks. None of the patients responded, one had stabilization of disease for 4 months. Haema-tologic toxicity was the major side effect with a nadir or white blood cell counts around day 40. Two patients died with severe leukopenia and septic shock. We conclude that mitozolomide is not active in this poor-risk group of patients.

Original language	English
Pages (from-to)	663-665
Number of pages	3
Journal	Acta Oncologica
Volume	28
Issue number	5
DOIs	https://doi.org/10.3109/02841868909092290
Publication status	Published - 1989

Keywords

Advanced ovarian cancer
Mitozolomide
Phase II study

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Hematology

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10.3109/02841868909092290

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abstract = "Twenty-seven fully evaluable patients with advanced ovarian cancer and documented disease progression despite cytotoxic treatment were treated with mitozolomide (NCS-353451) 90 mg/m2 as a 1-h infusion once every 6 weeks. None of the patients responded, one had stabilization of disease for 4 months. Haema-tologic toxicity was the major side effect with a nadir or white blood cell counts around day 40. Two patients died with severe leukopenia and septic shock. We conclude that mitozolomide is not active in this poor-risk group of patients.",

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AU - van der Burg, M. E L

AU - Guastalla, J. P.

AU - George, M.

AU - Piccart, M.

AU - Vermorken, J.

AU - Carnino, F.

AU - Rotmensz, N.

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Phase ii trial of mitozolomide in patients with advanced ovarian cancer: A study of the eortc gynecological cancer cooperative group

Abstract

Keywords

ASJC Scopus subject areas

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