Phase III Randomized Study of Induction Chemotherapy Followed by Definitive Radiotherapy + Cetuximab Versus Chemoradiotherapy in Squamous Cell Carcinoma of Head and Neck: The INTERCEPTOR-GONO Study (NCT00999700)

Marco Carlo Merlano, Nerina Denaro, Stefania Vecchio, Lisa Licitra, Paola Curcio, Marco Benasso, Almalina Bagicalupo, Gianmauro Numico, Elvio Russi, Renzo Corvo', Paolo Bruzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Induction chemotherapy followed by cetuximab and RT (IBRT) (Arm A) was compared to cisplatin/RT (CRT) (Arm B) in a randomized phase III study. Patients and Methods: Naïve patients with stage III-IVa, histologically proven locally advanced head and neck cancer (LASCCHN) were eligible. Arm A (IBRT): 3 TPF induction followed by cetuximab-RT (equivalent daily dose 2 Gy up to 70 Gy); Arm B: 3 cisplatin concurrent with the same RT scheduling. Due to slow accrual and incomplete data collection a futility analysis was performed. Results: 236/282 patients were evaluable. Therefore, no formal analyses can be made between the two arms. OS was 45.2/53.6 months in Arm A/B. Complete responses were achieved in 64% of patients in both arms. Neutropenia and skin toxicity were significantly worse in Arm A and body weight loss was significantly worse in Arm B. Compliance with the planned drug administration was higher in Arm B (p = 0.0008). Conclusion: The study suggests that IBRT and CRT have similar efficacy, activity and toxicity.

Original languageEnglish
JournalONCOLOGY (United States)
DOIs
Publication statusAccepted/In press - 2020

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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