Phase III study with FOLFIRI + cetuximab versus FOLFIRI + cetuximab followed by cetuximab alone in RAS and BRAF WT mCRC

Carmine Pinto, Nicola Normanno, Armando Orlandi, Francesca Fenizia, Angela Damato, Evaristo Maiello, Emiliano Tamburini, Francesco Di Costanzo, Giuseppe Tonini, Domenico Bilancia, Domenico Corsi, Salvatore Pisconti, Francesco Ferrau, Stefania Gori, Bruno Daniele, Alberto Zaniboni, Héctor Soto Parra, Giovanni Luca Frassinetti, Rosario Vincenzo Iaffaioli, Maria Giulia ZampinoLazzaro Repetto, Maria Alessandra Calegari, Carlo Barone

Research output: Contribution to journalArticle

Abstract

The optimal duration and intensity of first-line therapy in metastatic colorectal cancer patients once they have achieved an objective response is controversial. In a molecularly selected RAS and BRAF wild-type (wt) population, this concern is amplified. Once disease control has been achieved with a combination therapy including an anti-EGFR antibody, further exposure both to cytotoxic drugs and targeted therapy might result only in increased toxicity. In unresectable metastatic RAS and BRAF wt colorectal cancer patients, a deintensified therapy could represent a valuable option that might preserve quality of life. We designed a study to compare FOLFIRI/cetuximab to FOLFIRI/cetuximab for eight cycles followed by cetuximab alone in first-line treatment of RAS and BRAF (wt) metastatic colorectal cancer patients.

Original languageEnglish
JournalFuture Oncology
DOIs
Publication statusPublished - 2018

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Colorectal Neoplasms
Therapeutics
Anti-Idiotypic Antibodies
Quality of Life
Drug Therapy
Cetuximab
Population

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Phase III study with FOLFIRI + cetuximab versus FOLFIRI + cetuximab followed by cetuximab alone in RAS and BRAF WT mCRC. / Pinto, Carmine; Normanno, Nicola; Orlandi, Armando; Fenizia, Francesca; Damato, Angela; Maiello, Evaristo; Tamburini, Emiliano; Di Costanzo, Francesco; Tonini, Giuseppe; Bilancia, Domenico; Corsi, Domenico; Pisconti, Salvatore; Ferrau, Francesco; Gori, Stefania; Daniele, Bruno; Zaniboni, Alberto; Soto Parra, Héctor; Frassinetti, Giovanni Luca; Iaffaioli, Rosario Vincenzo; Zampino, Maria Giulia; Repetto, Lazzaro; Calegari, Maria Alessandra; Barone, Carlo.

In: Future Oncology, 2018.

Research output: Contribution to journalArticle

Pinto, C, Normanno, N, Orlandi, A, Fenizia, F, Damato, A, Maiello, E, Tamburini, E, Di Costanzo, F, Tonini, G, Bilancia, D, Corsi, D, Pisconti, S, Ferrau, F, Gori, S, Daniele, B, Zaniboni, A, Soto Parra, H, Frassinetti, GL, Iaffaioli, RV, Zampino, MG, Repetto, L, Calegari, MA & Barone, C 2018, 'Phase III study with FOLFIRI + cetuximab versus FOLFIRI + cetuximab followed by cetuximab alone in RAS and BRAF WT mCRC', Future Oncology. https://doi.org/10.2217/fon-2017-0592
Pinto, Carmine ; Normanno, Nicola ; Orlandi, Armando ; Fenizia, Francesca ; Damato, Angela ; Maiello, Evaristo ; Tamburini, Emiliano ; Di Costanzo, Francesco ; Tonini, Giuseppe ; Bilancia, Domenico ; Corsi, Domenico ; Pisconti, Salvatore ; Ferrau, Francesco ; Gori, Stefania ; Daniele, Bruno ; Zaniboni, Alberto ; Soto Parra, Héctor ; Frassinetti, Giovanni Luca ; Iaffaioli, Rosario Vincenzo ; Zampino, Maria Giulia ; Repetto, Lazzaro ; Calegari, Maria Alessandra ; Barone, Carlo. / Phase III study with FOLFIRI + cetuximab versus FOLFIRI + cetuximab followed by cetuximab alone in RAS and BRAF WT mCRC. In: Future Oncology. 2018.
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abstract = "The optimal duration and intensity of first-line therapy in metastatic colorectal cancer patients once they have achieved an objective response is controversial. In a molecularly selected RAS and BRAF wild-type (wt) population, this concern is amplified. Once disease control has been achieved with a combination therapy including an anti-EGFR antibody, further exposure both to cytotoxic drugs and targeted therapy might result only in increased toxicity. In unresectable metastatic RAS and BRAF wt colorectal cancer patients, a deintensified therapy could represent a valuable option that might preserve quality of life. We designed a study to compare FOLFIRI/cetuximab to FOLFIRI/cetuximab for eight cycles followed by cetuximab alone in first-line treatment of RAS and BRAF (wt) metastatic colorectal cancer patients.",
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AU - Pinto, Carmine

AU - Normanno, Nicola

AU - Orlandi, Armando

AU - Fenizia, Francesca

AU - Damato, Angela

AU - Maiello, Evaristo

AU - Tamburini, Emiliano

AU - Di Costanzo, Francesco

AU - Tonini, Giuseppe

AU - Bilancia, Domenico

AU - Corsi, Domenico

AU - Pisconti, Salvatore

AU - Ferrau, Francesco

AU - Gori, Stefania

AU - Daniele, Bruno

AU - Zaniboni, Alberto

AU - Soto Parra, Héctor

AU - Frassinetti, Giovanni Luca

AU - Iaffaioli, Rosario Vincenzo

AU - Zampino, Maria Giulia

AU - Repetto, Lazzaro

AU - Calegari, Maria Alessandra

AU - Barone, Carlo

PY - 2018

Y1 - 2018

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U2 - 10.2217/fon-2017-0592

DO - 10.2217/fon-2017-0592

M3 - Article

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JO - Future Oncology

JF - Future Oncology

SN - 1479-6694

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