Abstract
In cultured lymphocytes from 12 epileptic children on long term medication with phénobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.
| Original language | English |
|---|---|
| Pages (from-to) | 138-141 |
| Number of pages | 4 |
| Journal | Drug Investigation |
| Volume | 2 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1990 |
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ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
Phenobarbital Enhances Sister Chromatid Exchanges In Vivo. / Bellini, Carlo; Bonioli, Eugenio.
In: Drug Investigation, Vol. 2, No. 2, 1990, p. 138-141.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Phenobarbital Enhances Sister Chromatid Exchanges In Vivo
AU - Bellini, Carlo
AU - Bonioli, Eugenio
PY - 1990
Y1 - 1990
N2 - In cultured lymphocytes from 12 epileptic children on long term medication with phénobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.
AB - In cultured lymphocytes from 12 epileptic children on long term medication with phénobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025182547&partnerID=8YFLogxK
U2 - 10.1007/BF03258255
DO - 10.1007/BF03258255
M3 - Article
VL - 2
SP - 138
EP - 141
JO - Drug Investigation
JF - Drug Investigation
SN - 0114-2402
IS - 2
ER -