Phenobarbital Enhances Sister Chromatid Exchanges In Vivo

Carlo Bellini, Eugenio Bonioli

Research output: Contribution to journalArticlepeer-review


In cultured lymphocytes from 12 epileptic children on long term medication with phénobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.

Original languageEnglish
Pages (from-to)138-141
Number of pages4
JournalDrug Investigation
Issue number2
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Pharmacology (medical)


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