Abstract
In cultured lymphocytes from 12 epileptic children on long term medication with phénobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.
Original language | English |
---|---|
Pages (from-to) | 138-141 |
Number of pages | 4 |
Journal | Drug Investigation |
Volume | 2 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1990 |
ASJC Scopus subject areas
- Pharmacology (medical)