Abstract
In cultured lymphocytes from 12 epileptic children on long term medication with phénobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.
| Original language | English |
|---|---|
| Pages (from-to) | 138-141 |
| Number of pages | 4 |
| Journal | Drug Investigation |
| Volume | 2 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1990 |
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ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
Bellini, C., & Bonioli, E. (1990). Phenobarbital Enhances Sister Chromatid Exchanges In Vivo. Drug Investigation, 2(2), 138-141. https://doi.org/10.1007/BF03258255