Phenobarbital Enhances Sister Chromatid Exchanges In Vivo

Carlo Bellini, Eugenio Bonioli

Research output: Contribution to journalArticle

Abstract

In cultured lymphocytes from 12 epileptic children on long term medication with phénobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.

Original languageEnglish
Pages (from-to)138-141
Number of pages4
JournalDrug Investigation
Volume2
Issue number2
DOIs
Publication statusPublished - 1990

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ASJC Scopus subject areas

  • Pharmacology (medical)

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