Phenobarbital Enhances Sister Chromatid Exchanges In Vivo

Carlo Bellini; Eugenio Bonioli

doi:10.1007/BF03258255

Phenobarbital Enhances Sister Chromatid Exchanges In Vivo

Carlo Bellini, Eugenio Bonioli

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

In cultured lymphocytes from 12 epileptic children on long term medication with phénobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.

Original language	English
Pages (from-to)	138-141
Number of pages	4
Journal	Drug Investigation
Volume	2
Issue number	2
DOIs	https://doi.org/10.1007/BF03258255
Publication status	Published - 1990

ASJC Scopus subject areas

Pharmacology (medical)

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title = "Phenobarbital Enhances Sister Chromatid Exchanges In Vivo",

abstract = "In cultured lymphocytes from 12 epileptic children on long term medication with ph{\'e}nobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.",

author = "Carlo Bellini and Eugenio Bonioli",

year = "1990",

doi = "10.1007/BF03258255",

language = "English",

volume = "2",

pages = "138--141",

journal = "Clinical Drug Investigation",

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number = "2",

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AU - Bellini, Carlo

AU - Bonioli, Eugenio

PY - 1990

Y1 - 1990

N2 - In cultured lymphocytes from 12 epileptic children on long term medication with phénobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.

AB - In cultured lymphocytes from 12 epileptic children on long term medication with phénobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.

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DO - 10.1007/BF03258255

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JO - Clinical Drug Investigation

JF - Clinical Drug Investigation

SN - 1173-2563

IS - 2

ER -

Phenobarbital Enhances Sister Chromatid Exchanges In Vivo

Abstract

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