Phenobarbital Enhances Sister Chromatid Exchanges In Vivo

Carlo Bellini, Eugenio Bonioli

Research output: Contribution to journal › Article

Abstract

In cultured lymphocytes from 12 epileptic children on long term medication with phénobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.

Original languageEnglish
Pages (from-to)138-141
Number of pages4
JournalDrug Investigation
Volume2
Issue number2
DOIs
Publication statusPublished - 1990

Fingerprint

Sister Chromatid Exchange
Phenobarbital
Chromatids
Lymphocytes
Control Groups
DNA

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Phenobarbital Enhances Sister Chromatid Exchanges In Vivo. / Bellini, Carlo; Bonioli, Eugenio.

In: Drug Investigation, Vol. 2, No. 2, 1990, p. 138-141.

Research output: Contribution to journal › Article

Bellini, C & Bonioli, E 1990, 'Phenobarbital Enhances Sister Chromatid Exchanges In Vivo', Drug Investigation, vol. 2, no. 2, pp. 138-141. https://doi.org/10.1007/BF03258255
Bellini C, Bonioli E. Phenobarbital Enhances Sister Chromatid Exchanges In Vivo. Drug Investigation. 1990;2(2):138-141. https://doi.org/10.1007/BF03258255
Bellini, Carlo ; Bonioli, Eugenio. / Phenobarbital Enhances Sister Chromatid Exchanges In Vivo. In: Drug Investigation. 1990 ; Vol. 2, No. 2. pp. 138-141.
@article{34becd18508b49429ef153760245e3da,
title = "Phenobarbital Enhances Sister Chromatid Exchanges In Vivo",
abstract = "In cultured lymphocytes from 12 epileptic children on long term medication with ph{\'e}nobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42{\%}. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.",
author = "Carlo Bellini and Eugenio Bonioli",
year = "1990",
doi = "10.1007/BF03258255",
language = "English",
volume = "2",
pages = "138--141",
journal = "Clinical Drug Investigation",
issn = "1173-2563",
publisher = "Adis Press",
number = "2",

}

TY - JOUR

T1 - Phenobarbital Enhances Sister Chromatid Exchanges In Vivo

AU - Bellini, Carlo

AU - Bonioli, Eugenio

PY - 1990

Y1 - 1990

N2 - In cultured lymphocytes from 12 epileptic children on long term medication with phénobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.

AB - In cultured lymphocytes from 12 epileptic children on long term medication with phénobarbital, an increased sister chromatid exchange frequency was found, the average chromatid exchange rate exceeding that of a normal control group by 42%. This consistent increase in sister chromatid exchanges indicates a possible DNA-dam-aging effect of phenobarbital.

UR - http://www.scopus.com/inward/record.url?scp=0025182547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025182547&partnerID=8YFLogxK

U2 - 10.1007/BF03258255

DO - 10.1007/BF03258255

M3 - Article

AN - SCOPUS:0025182547

VL - 2

SP - 138

EP - 141

JO - Clinical Drug Investigation

JF - Clinical Drug Investigation

SN - 1173-2563

IS - 2

ER -

Access to Document