Phenotypic analysis of a CD2- CD3+ T cell receptor gamma delta lymphocyte subset

P. de Paoli, D. Gennari, G. Basaglia, P. Martelli, G. Santini

Research output: Contribution to journalArticle

Abstract

We have identified, in a patient with atopic dermatitis, a consistent population of peripheral blood lymphocytes expressing a CD3+ γ δ TCR complex, while being unreactive with CD2. Further immunoflourescence studies showed that these cells almost completely co-express CD29 and CD45RA and have high membrane levels of CD11a compared to the α β TCR T cells. Neither a genetic influence nor an acute or reactivated herpesvirus infection were found to be related to the expanded γ δ T-cell subpopulation. Our data confirm the previous observations regarding the presence in the peripheral blood of an expanded γ δ TCR, CD2- subset and show that these cells have a peculiar phenotypic profile. The reasons for this expansion are, however, still unknown.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalImmunology Letters
Volume23
Issue number3
DOIs
Publication statusPublished - 1990

Keywords

  • CD2
  • Epstein-Barr virus
  • Gamma-delta T cell
  • Leukocyte integrin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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