Phenotypic analysis of a CD2- CD3+ T cell receptor gamma delta lymphocyte subset

P. de Paoli, D. Gennari, G. Basaglia, P. Martelli, G. Santini

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We have identified, in a patient with atopic dermatitis, a consistent population of peripheral blood lymphocytes expressing a CD3+ γ δ TCR complex, while being unreactive with CD2. Further immunoflourescence studies showed that these cells almost completely co-express CD29 and CD45RA and have high membrane levels of CD11a compared to the α β TCR T cells. Neither a genetic influence nor an acute or reactivated herpesvirus infection were found to be related to the expanded γ δ T-cell subpopulation. Our data confirm the previous observations regarding the presence in the peripheral blood of an expanded γ δ TCR, CD2- subset and show that these cells have a peculiar phenotypic profile. The reasons for this expansion are, however, still unknown.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalImmunology Letters
Volume23
Issue number3
DOIs
Publication statusPublished - 1990

Fingerprint

Antigen Receptors, T-Cell, gamma-delta
Lymphocyte Subsets
T-Cell Antigen Receptor-CD3 Complex
T-Lymphocytes
Herpesviridae Infections
Atopic Dermatitis
Lymphocytes
Membranes
Population

Keywords

  • CD2
  • Epstein-Barr virus
  • Gamma-delta T cell
  • Leukocyte integrin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Phenotypic analysis of a CD2- CD3+ T cell receptor gamma delta lymphocyte subset. / de Paoli, P.; Gennari, D.; Basaglia, G.; Martelli, P.; Santini, G.

In: Immunology Letters, Vol. 23, No. 3, 1990, p. 195-198.

Research output: Contribution to journalArticle

de Paoli, P. ; Gennari, D. ; Basaglia, G. ; Martelli, P. ; Santini, G. / Phenotypic analysis of a CD2- CD3+ T cell receptor gamma delta lymphocyte subset. In: Immunology Letters. 1990 ; Vol. 23, No. 3. pp. 195-198.
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