Phenotypic and functional heterogeneity of human T lymphocytes producing B-cell growth factor(s): A clonal analysis

E. Maggi, M. C. Mingari, F. Almerigogna, F. Gerosa, L. Moretta, S. Romagnani

Research output: Contribution to journalArticle

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Abstract

Human T cells active on B-cell proliferation are phenotypically and functionally heterogeneous. A series of 43 human T-cell clones, selected according to their ability to release factors active on B-cell proliferation, were analyzed. B-Cell proliferation was evaluated by two different assays, namely, a costimulation assay with anti-μ antibody or by an assay based on B-cell preactivation with Staphylococcus aureus. Eight of these clones expressed the T4- T8+ phenotype while the remaining were T4+ T8-. The large majority had T-cell growth factor activity as well. However, some clones appeared to have B-cell growth factor activity only. Fourteen clones (eight T8+ and six T4+) also displayed cytolytic activity in a phytohemagglutinin-dependent cytolytic assay.

Original languageEnglish
Pages (from-to)168-175
Number of pages8
JournalClinical Immunology and Immunopathology
Volume36
Issue number2
DOIs
Publication statusPublished - 1985

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Intercellular Signaling Peptides and Proteins
B-Lymphocytes
T-Lymphocytes
Clone Cells
Cell Proliferation
Phytohemagglutinins
Interleukin-2
Staphylococcus aureus
Anti-Idiotypic Antibodies
Phenotype

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Phenotypic and functional heterogeneity of human T lymphocytes producing B-cell growth factor(s) : A clonal analysis. / Maggi, E.; Mingari, M. C.; Almerigogna, F.; Gerosa, F.; Moretta, L.; Romagnani, S.

In: Clinical Immunology and Immunopathology, Vol. 36, No. 2, 1985, p. 168-175.

Research output: Contribution to journalArticle

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AU - Romagnani, S.

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