Abstract
Human T cells active on B-cell proliferation are phenotypically and functionally heterogeneous. A series of 43 human T-cell clones, selected according to their ability to release factors active on B-cell proliferation, were analyzed. B-Cell proliferation was evaluated by two different assays, namely, a costimulation assay with anti-μ antibody or by an assay based on B-cell preactivation with Staphylococcus aureus. Eight of these clones expressed the T4- T8+ phenotype while the remaining were T4+ T8-. The large majority had T-cell growth factor activity as well. However, some clones appeared to have B-cell growth factor activity only. Fourteen clones (eight T8+ and six T4+) also displayed cytolytic activity in a phytohemagglutinin-dependent cytolytic assay.
| Original language | English |
|---|---|
| Pages (from-to) | 168-175 |
| Number of pages | 8 |
| Journal | Clinical Immunology and Immunopathology |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1985 |
Fingerprint
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Pathology and Forensic Medicine
Cite this
Phenotypic and functional heterogeneity of human T lymphocytes producing B-cell growth factor(s) : A clonal analysis. / Maggi, E.; Mingari, M. C.; Almerigogna, F.; Gerosa, F.; Moretta, L.; Romagnani, S.
In: Clinical Immunology and Immunopathology, Vol. 36, No. 2, 1985, p. 168-175.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Phenotypic and functional heterogeneity of human T lymphocytes producing B-cell growth factor(s)
T2 - A clonal analysis
AU - Maggi, E.
AU - Mingari, M. C.
AU - Almerigogna, F.
AU - Gerosa, F.
AU - Moretta, L.
AU - Romagnani, S.
PY - 1985
Y1 - 1985
N2 - Human T cells active on B-cell proliferation are phenotypically and functionally heterogeneous. A series of 43 human T-cell clones, selected according to their ability to release factors active on B-cell proliferation, were analyzed. B-Cell proliferation was evaluated by two different assays, namely, a costimulation assay with anti-μ antibody or by an assay based on B-cell preactivation with Staphylococcus aureus. Eight of these clones expressed the T4- T8+ phenotype while the remaining were T4+ T8-. The large majority had T-cell growth factor activity as well. However, some clones appeared to have B-cell growth factor activity only. Fourteen clones (eight T8+ and six T4+) also displayed cytolytic activity in a phytohemagglutinin-dependent cytolytic assay.
AB - Human T cells active on B-cell proliferation are phenotypically and functionally heterogeneous. A series of 43 human T-cell clones, selected according to their ability to release factors active on B-cell proliferation, were analyzed. B-Cell proliferation was evaluated by two different assays, namely, a costimulation assay with anti-μ antibody or by an assay based on B-cell preactivation with Staphylococcus aureus. Eight of these clones expressed the T4- T8+ phenotype while the remaining were T4+ T8-. The large majority had T-cell growth factor activity as well. However, some clones appeared to have B-cell growth factor activity only. Fourteen clones (eight T8+ and six T4+) also displayed cytolytic activity in a phytohemagglutinin-dependent cytolytic assay.
UR - http://www.scopus.com/inward/record.url?scp=0021874255&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021874255&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(85)90118-7
DO - 10.1016/0090-1229(85)90118-7
M3 - Article
C2 - 3924456
AN - SCOPUS:0021874255
VL - 36
SP - 168
EP - 175
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
SN - 0090-1229
IS - 2
ER -