Phenotypic and functional heterogeneity of human T lymphocytes producing B-cell growth factor(s): A clonal analysis

E. Maggi, M. C. Mingari, F. Almerigogna, F. Gerosa, L. Moretta, S. Romagnani

Research output: Contribution to journalArticlepeer-review

Abstract

Human T cells active on B-cell proliferation are phenotypically and functionally heterogeneous. A series of 43 human T-cell clones, selected according to their ability to release factors active on B-cell proliferation, were analyzed. B-Cell proliferation was evaluated by two different assays, namely, a costimulation assay with anti-μ antibody or by an assay based on B-cell preactivation with Staphylococcus aureus. Eight of these clones expressed the T4- T8+ phenotype while the remaining were T4+ T8-. The large majority had T-cell growth factor activity as well. However, some clones appeared to have B-cell growth factor activity only. Fourteen clones (eight T8+ and six T4+) also displayed cytolytic activity in a phytohemagglutinin-dependent cytolytic assay.

Original languageEnglish
Pages (from-to)168-175
Number of pages8
JournalClinical Immunology and Immunopathology
Volume36
Issue number2
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

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