Phenotypic and functional properties of γδ T Cells from patients with Guillain Barre syndrome

Giovanna Borsellino, Fabrizio Poccia, Roberta Placido, Daniela Tramonti, Giorgio Mancino, Sabina Luchetti, Simona Galgani, Bruno Bonetti, Simona Bach, Barbara Cipriani, Celia F. Brosnan, Luca Battistini

Research output: Contribution to journalArticlepeer-review


In this study we have examined the phenotypic and functional properties of circulating γδ T cells in patients with Guillain Barre syndrome (GBS), in normal healthy controls, and in patients with active multiple sclerosis (MS). Cells expressing the Vδ2 T cell receptor showed elevated expression of the C-lectin receptor NKRP1A in both GBS and MS, suggestive of an activated state. However, in patients with GBS these cells failed to respond to pyrenil-pyrophosphate derivatives and Vδ2+ T cell clones derived from these patients released lower levels of IFNγ than Vδ2+ clones derived from controls and MS patients. In contrast, in patients with GBS the Vδ1+ subset was expanded, showed elevated expression of NKRP1A and Vδ1+ clones derived from these patients secreted high levels of IL-4. Our findings of expanded NKRP-1A+, IL-4-producing Vδ1 T cells in the GBS patients suggests the possibility that these cells are activated by the recognition of non-protein antigens in an MHC-unrestricted manner and contribute to the humoral response to glycolipids that is a hallmark of this disease. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)199-207
Number of pages9
JournalJournal of Neuroimmunology
Issue number2
Publication statusPublished - Jan 24 2000


  • Cytokines
  • Gamma-delta T cells
  • Guillain Barre Syndrome

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology


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