Phenotypic and genotypic characterization of a CD4+ cell clone from the peripheral blood of a patient with cutaneous T cell lymphoma

G. De Franchis, L. Salvagno, E. D'Andrea, S. Valverde, A. Del Mistro, M. M. Salvadego, O. Daniele

Research output: Contribution to journalArticle

Abstract

A 52 year old man with a stage IV cutaneous CD4+ cell lymphoma was referred to the Oncology Department for peripheral blood lymphocyte immunophenotyping. The blood cell count showed a normal number of lymphocytes but cytofluorimetric analysis presented a scatter emission in the CD4+/CD3+ lymphocytes enabling us to divide them into two distinct subsets characterized by the different membrane density of the CD4 antigen: a CD4+ lymphocyte subset with a decreased surface concentration of the CD4 antigen (dim) appeared alongside a CD4+ population in which the antigen was normally represented (bright). The patient underwent chemotherapy treatment for a six-month period. We observed a correlation between therapy, changes in the double CD4 population and an improvement in the patient's condition. In fact, the 'dim' CD4+ population number progressively decreased in relation to the clinical improvement during chemotherapy. We suggest that this lymphocyte population might be of neoplastic origin.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalEuropean Journal of Laboratory Medicine
Volume2
Issue number3
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Medicine(all)

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