A 52 year old man with a stage IV cutaneous CD4+ cell lymphoma was referred to the Oncology Department for peripheral blood lymphocyte immunophenotyping. The blood cell count showed a normal number of lymphocytes but cytofluorimetric analysis presented a scatter emission in the CD4+/CD3+ lymphocytes enabling us to divide them into two distinct subsets characterized by the different membrane density of the CD4 antigen: a CD4+ lymphocyte subset with a decreased surface concentration of the CD4 antigen (dim) appeared alongside a CD4+ population in which the antigen was normally represented (bright). The patient underwent chemotherapy treatment for a six-month period. We observed a correlation between therapy, changes in the double CD4 population and an improvement in the patient's condition. In fact, the 'dim' CD4+ population number progressively decreased in relation to the clinical improvement during chemotherapy. We suggest that this lymphocyte population might be of neoplastic origin.
|Number of pages||4|
|Journal||European Journal of Laboratory Medicine|
|Publication status||Published - 1994|
ASJC Scopus subject areas