Phenotypic characterization of tumor CTLA-4 expression in melanoma tissues and its possible role in clinical response to Ipilimumab: Clinical Immunology

M.P. Pistillo, R. Carosio, F. Grillo, V. Fontana, L. Mastracci, A. Morabito, B. Banelli, E. Tanda, F. Cecchi, B. Dozin, M. Gualco, S. Salvi, F. Spagnolo, A. Poggi, P. Queirolo

Research output: Contribution to journalArticlepeer-review

Abstract

The expression of the immune checkpoint molecule CTLA-4 has been almost exclusively studied in the T cell lineage, but increasing evidence has shown its expression on tumors with implications for immunotherapy. To date, the degree of expression of CTLA-4 on tumor cells as a predictive biomarker of response to immune checkpoint inhibitors has not been studied. In this report, we analyzed this issue in melanoma patients treated with CTLA-4 inhibitor Ipilimumab (IPI). We show that the level of CTLA-4 expression on melanoma cells is higher than that on tumor infiltrating lymphocytes (TIL) and it is associated with clinical response to IPI therapy supporting the idea of its possible role as a predictive biomarker. © 2020
Original languageEnglish
JournalClin. Immunol.
Volume215
DOIs
Publication statusPublished - 2020

Keywords

  • Best overall response
  • CTLA-4
  • Immunohistochemistry
  • Ipilimumab
  • Melanoma
  • TIL
  • biological marker
  • CD20 antigen
  • CD3 antigen
  • CD4 antigen
  • CD45RO antigen
  • CD56 antigen
  • CD8 antigen
  • cytotoxic T lymphocyte antigen 4
  • ipilimumab
  • tumor marker
  • adult
  • aged
  • Article
  • B lymphocyte
  • CD3+ T lymphocyte
  • CD4+ T lymphocyte
  • CD8+ T lymphocyte
  • cellular distribution
  • clinical article
  • cutaneous melanoma
  • drug response
  • female
  • gene overexpression
  • human
  • human cell
  • human tissue
  • immunophenotyping
  • male
  • melanoma
  • melanoma cell
  • middle aged
  • mucosal melanoma
  • priority journal
  • protein expression level
  • T lymphocyte subpopulation
  • tissue distribution
  • treatment response
  • tumor associated leukocyte

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