Phenotypic, cytogenetic and molecular characterization of a new B-chronic lymphocytic leukaemia (B-CLL) cell line

Federico Caligaris-Cappio, Luciana Bergui, Giovanna Rege-Cambrin, Luisa Tesio, Nicola Migone, Fabio Malavasi

Research output: Contribution to journalArticle

Abstract

A lymphoid cell line was established from a patient with B-cell chronic lymphocytic leukaemia (B-CLL) by infecting blood lymphocytes with Epstein-Barr virus (EBV). Immunoglobulin gene rearrangement studies and the presence of a chromosome marker (isochromosome 17q) provided the formal proof that the line has originated from the neoplastic B cells. The morphology and phenotype indicate that the EBV-induced cell line has reached a plasma cell-like stage of differentiation.

Original languageEnglish
Pages (from-to)579-588
Number of pages10
JournalLeukemia Research
Volume11
Issue number7
DOIs
Publication statusPublished - 1987

Keywords

  • B-chronic lymphocytic leukaemia (B-CLL)
  • EBV

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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    Caligaris-Cappio, F., Bergui, L., Rege-Cambrin, G., Tesio, L., Migone, N., & Malavasi, F. (1987). Phenotypic, cytogenetic and molecular characterization of a new B-chronic lymphocytic leukaemia (B-CLL) cell line. Leukemia Research, 11(7), 579-588. https://doi.org/10.1016/0145-2126(87)90029-4