Phenotypic diversity in chondromyxoid fibroma reveals differentiation pattern of tumor mimicking fetal cartilage canals development

An immunohistochemical study

Jozef Zustin, Hana Akpalo, Marco Gambarotti, Matthias Priemel, Johannes M. Rueger, Andreas M. Luebke, Dennis Reske, Claudia Lange, Klaus Pueschel, Christoph Lohmann, Wolfgang Rüther, Michael Amling, Marco Alberghini

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Chondromyxoid fibroma represents a rare benign cartilaginous tumor of young patients occurring in a subcortical metaphyseal location. The histogenesis of chondromyxoid fibroma has not yet been postulated, even though the conventional histology and recent immunohistochemical studies on phenotype of the mesenchymal cells and extracellular matrix components suggested its origin in immature cartilage. Therefore, we wished to compare the morphological pattern of immature cartilage tissue with chondromyxoid fibroma to investigate a possible developmental counterpart of chondromyxoid fibroma. Archival paraffin-embedded tissues from 4 fetal femora and 10 cases of chondromyxoid fibroma were analyzed simultaneously using histochemistry (safranin O) and established immunohistochemical antibodies (CD34, CD163, and smooth muscle actin). Vascularized cartilage canals growing into the fetal cartilage from the perichondrium displayed characteristic glomeruloid structures with central arterioles within the immature mesenchymal stroma and numerous superficial sinusoidal blood vessels accompanied by macrophage infiltration. Similarly, each case of chondromyxoid fibroma demonstrated admixture of two characteristic components: immature fibrous tissue of vascularized stroma with accumulation of macrophages in areas of superficial sinusoidal proliferation, and variable amounts of lobulated chondroid tissue. Based on the observed substantial morphological similarity between the cartilage canals and chondromyxoid fibroma, we suggest that the chondromyxoid fibroma represents a neoplasm originating from or mimicking the fetal cartilage canals within the immature cartilage.

Original languageEnglish
Pages (from-to)1072-1078
Number of pages7
JournalAmerican Journal of Pathology
Volume177
Issue number3
DOIs
Publication statusPublished - Sep 2010

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Fibroma
Cartilage
Neoplasms
Macrophages
Arterioles
Paraffin
Femur
Extracellular Matrix
Smooth Muscle
Blood Vessels
Actins
Histology
Fetus
Phenotype
Antibodies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Phenotypic diversity in chondromyxoid fibroma reveals differentiation pattern of tumor mimicking fetal cartilage canals development : An immunohistochemical study. / Zustin, Jozef; Akpalo, Hana; Gambarotti, Marco; Priemel, Matthias; Rueger, Johannes M.; Luebke, Andreas M.; Reske, Dennis; Lange, Claudia; Pueschel, Klaus; Lohmann, Christoph; Rüther, Wolfgang; Amling, Michael; Alberghini, Marco.

In: American Journal of Pathology, Vol. 177, No. 3, 09.2010, p. 1072-1078.

Research output: Contribution to journalArticle

Zustin, J, Akpalo, H, Gambarotti, M, Priemel, M, Rueger, JM, Luebke, AM, Reske, D, Lange, C, Pueschel, K, Lohmann, C, Rüther, W, Amling, M & Alberghini, M 2010, 'Phenotypic diversity in chondromyxoid fibroma reveals differentiation pattern of tumor mimicking fetal cartilage canals development: An immunohistochemical study', American Journal of Pathology, vol. 177, no. 3, pp. 1072-1078. https://doi.org/10.2353/ajpath.2010.100171
Zustin, Jozef ; Akpalo, Hana ; Gambarotti, Marco ; Priemel, Matthias ; Rueger, Johannes M. ; Luebke, Andreas M. ; Reske, Dennis ; Lange, Claudia ; Pueschel, Klaus ; Lohmann, Christoph ; Rüther, Wolfgang ; Amling, Michael ; Alberghini, Marco. / Phenotypic diversity in chondromyxoid fibroma reveals differentiation pattern of tumor mimicking fetal cartilage canals development : An immunohistochemical study. In: American Journal of Pathology. 2010 ; Vol. 177, No. 3. pp. 1072-1078.
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