Phenotypic shift in blast cells of acute lymphoblastic leukemia at relapse: Clinical and biological implications

N. Cascavilla, S. Ladogana, A. La Sala, L. Melillo, P. Musto, M. Nobile, M. Carotenuto

Research output: Contribution to journalArticle

Abstract

Analysis of lymphoid phenotypes was performed in 20 patients with Acute Lymphoblastic Leukemia (ALL) by cytofluorimetric assay with a large panel of monoclonal antibodies, at the time of diagnosis and at relapse. In 7 patients (35%) a relevant modification in surface antigen expression was found at the reappraisal of the disease. These subjects appeared less responsive to a second step of chemotherapy and showed a shorter survival. Thus, a more aggressive approach is probably needed in patients with significant phenotypic shift at relapse.

Original languageEnglish
Pages (from-to)64-66
Number of pages3
JournalMedicina - Rivista della Enciclopedia Medica Italiana
Volume8
Issue number1
Publication statusPublished - 1988

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Recurrence
Surface Antigens
Monoclonal Antibodies
Phenotype
Drug Therapy
Survival

ASJC Scopus subject areas

  • Medicine(all)

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Phenotypic shift in blast cells of acute lymphoblastic leukemia at relapse : Clinical and biological implications. / Cascavilla, N.; Ladogana, S.; La Sala, A.; Melillo, L.; Musto, P.; Nobile, M.; Carotenuto, M.

In: Medicina - Rivista della Enciclopedia Medica Italiana, Vol. 8, No. 1, 1988, p. 64-66.

Research output: Contribution to journalArticle

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AU - Carotenuto, M.

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