Phenylketonuria: Diet for life or not?

R. Cerone, M. C. Schiaffino, S. Di Stefano, E. Veneselli

Research output: Contribution to journalArticlepeer-review


In order to evaluate the argument whether or not a restricted phenylalanine diet should be maintained for life in patients with phenylketonuria (PKU), 16 patients with early treated PKU but off diet since their 11th birthday were investigated. The evaluation included a detailed neurological examination, IQ, neurophysiological testing and MRI of the brain. Even if IQ and electrophysiological studies were normal or unchanged if compared to results before diet discontinuation, all patients revealed abnormal neurological signs. We conclude that the diet should be continued during adult life, but somewhat higher phenylalanine levels (

Original languageEnglish
Pages (from-to)664-666
Number of pages3
JournalActa Paediatrica, International Journal of Paediatrics
Issue number6
Publication statusPublished - Jun 1999


  • Adolescence
  • Dietary treatment
  • Phenylketonuria

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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