The effect of viloxazine (VLX) on plasma levels of phenytoin (PHT) was evaluated in a group of 10 epileptic patients stabilized on PHT monotherapy. Addition of VLX induced an increase in PHT levels of 37,3% on average and caused the onset of PHT toxicity in 4 pts, who had to discontinue VLX before the established time. These data suggest that VLX inhibits PHT methabolism.
|Translated title of the contribution||Phenytoin-viloxazine interaction in patients with epilepsy|
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1990|
ASJC Scopus subject areas
- Clinical Neurology